Autoimmune Polyendocrine Syndrome
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Types
- There are two distinct types APS-1 and APS-2
- APS also named PAS
APS-1
Clinic
- APS-1 causes the dysfunction of multiple endocrine glands due to autoimmunity.
- It is an inherited in autosomal recessive fashion
Signs and symptoms
- Chronic mucocutaneous candidiasis
- Hypoparathyroidism
- Addison's disease
- Ectodermal dystrophy (Skin, Dental enamel, and Nails)
APS-1 may also cause:
- Autoimmune hepatitis
- Hypogonadism
- Vitiligo
- Alopecia
- Malabsorption
- Pernicious anemia
- Cataract
- Cerebellar ataxia
APS-1 Entity / Miasm
| HSV | EBV | CMV | HCV | MMP | |
|---|---|---|---|---|---|
| Hepatitis | +++ | +++ | +++ | +++ | +++ |
| Infertitiy | +++ | +++ | |||
| Vitiligo | +++ | +++ | |||
| Atrophic Gastritis | +++ | +++ | |||
| Cataract | + | ||||
| Cerebellar ataxia | +++ | +++ | +++ | ||
| Autoimmune adrenalitis | ++ | + | +++ | ||
| Alopecia | + |
APS-2
Clinic
- It is the most common form
- It is heterogeneous and has not been linked to one gene.
- It affects women to a greater degree than men.
Signs / Symptoms
- Hashimoto thyroiditis: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
- Low blood pressure
- Hypoparathyroidism
- Myalgia
- Graves' disease
- Anemia
- Hypogonadism
- Diabetes mellitus
APS-2 Entities / Miasms
| MTB | MMP | EBV | HCV | |
|---|---|---|---|---|
| Infertility | +++ | +++ | ||
| Hashimoto thyroiditis | +++ | +++ | +++ | +++ |
| Anemia | +++ | +++ | +++ | |
| Diabetes mellitus, juvenile | +++ |
Note
It seems that APS is a COE.