GSS, Gerstmann Straussler Scheinker syndrome: Difference between revisions

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* It is a [[prion]] [[Miasm list|miasm]]
* It is a [[prion]] [[Miasm list|miasm]]
*Typicaly includes progressive '''[[Cerebellar ataxia miasms|Cerebellar ataxia]]''' + [[Pyramidalism|Pyramidal tract signs]] + [[Pseudobulbar palsy|Pseudobulbar paralysis]] + [[Myoclonus entities|myoclonus]], + [[Hypo reflexia|Absent tendon reflexes]]. <ref>Zhao MM, Feng LS, Hou S, Shen PP, Cui L, Feng JC. Gerstmann-Sträussler-Scheinker disease: A case report. World J Clin Cases. 2019 Feb 6;7(3):389-395. doi: 10.12998/wjcc.v7.i3.389. PMID: 30746381; PMCID: PMC6369391.</ref> + '''[[Dysesthesia miasms|Dysesthesia]]'''
*Typicaly includes progressive '''[[Cerebellar ataxia]]''' + [[Pyramidal system|Pyramidal tract signs]] + [[Pseudobulbar palsy|Pseudobulbar paralysis]] + [[myoclonus]], + [[Hypo reflexia|Absent tendon reflexes]]. <ref>Zhao MM, Feng LS, Hou S, Shen PP, Cui L, Feng JC. Gerstmann-Sträussler-Scheinker disease: A case report. World J Clin Cases. 2019 Feb 6;7(3):389-395. doi: 10.12998/wjcc.v7.i3.389. PMID: 30746381; PMCID: PMC6369391.</ref> + '''[[Dysesthesia]]'''




=== [[Parkinsonism]] ===
=== [[Parkinsonism]] ===
*''[[Tremor miasms|Tremor]]''
*''[[Tremor]]''
*''[[Spasticity miasms|Spasticity]]: Rigid muscle tone and progressive muscle stiffness and weakness, causing abnormal, writhing movements''
*''[[Spasticity]]: Rigid muscle tone and progressive muscle stiffness and weakness, causing abnormal, writhing movements''
*[[Bradykinesia miasms|Bradykinesia]]: abnormal slowness of movement <ref>NORD</ref>
*Bradykinesia: abnormal slowness of movement <ref>NORD</ref>
*[[Myoclonus entities|Myoclonus]]  
*[[Myoclonus]]





Revision as of 03:34, 25 September 2023

Clinic


Parkinsonism

  • Tremor
  • Spasticity: Rigid muscle tone and progressive muscle stiffness and weakness, causing abnormal, writhing movements
  • Bradykinesia: abnormal slowness of movement [2]
  • Myoclonus


Initial symptoms

  • Paralysis: , Paraplegia / Paraparesis
  • Visual disturbances/ Blindness
  • Seizures
  • Movements disorders such as Jerking, Myoclonus
  • Deafness: Less commonly, hearing loss or deafness will develop


Athetosis

  • Slow, writhing, involuntary movements

Depression

  • Hypomimia or Masked faces: Reduced degree of facial expression / Emotion
  • bradyphrenia


Dementia

  • Cognitive dysfunction leading to bradyphrenia
  • Cognition impairment such as problems in thinking, remembering, reasoning, imagining and processing thoughts which leads to Dementia[3]
  • In my research, GSS is the best remedy of Alzheimer disease, because of Memory weakness + Psychosis/ Behavioral change + Impaired Concentration + Depression


Cerebellar Ataxia

  • Nystagmus
  • Progressive Ataxia / Incoordination may present as unsteadiness, difficulty walking, and clumsiness /Awkwardness
  • Ocular dysmetria: Difficulties judging distance or scale
  • Slurred speech which progress to severe Spastic Dysarthria with UMN origin


Pyramidal signs / UMN

Corticospinal tract

Corticobulbar tract

Remedies

  1. Phos, Agar, Caust, Lach, Con
  2. Plb, Arg-n, Cocc, Calc, Sul, Stram , Nux-v
  1. Zhao MM, Feng LS, Hou S, Shen PP, Cui L, Feng JC. Gerstmann-Sträussler-Scheinker disease: A case report. World J Clin Cases. 2019 Feb 6;7(3):389-395. doi: 10.12998/wjcc.v7.i3.389. PMID: 30746381; PMCID: PMC6369391.
  2. NORD
  3. NORD Gratefully acknowledges Pawel P. Liberski, MD, PhD, Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland, for assistance in the preparation of this report.