EBV, Epstein Barr Virus

Clinic

• EBV is one of the nine known human herpesvirus types in the herpes family
• It is one of the most common viruses in humans.
• It is best known as the cause of infectious mononucleosis ("mono" or "glandular fever").

Related disease

• Lymphoproliferative diseases such as
  • Burkitt lymphoma
  • Hemophagocytic lymphohistiocytosis
  • Hodgkin's lymphoma
• Non-lymphoid malignancies such as
  • Gastric cancer
  • External throat: Nasopharyngeal carcinoma
  • Jaw tumor
  • Pericardial tumor
  • Breast; cancer
  • Pleural tumor
  • Liver; cancer
• Conditions associated with HIV such as
  • Oral Hairy leukoplakia : White or red discoloration of tongue. Tongue; white lesion on the lateral.
  • CNS lymphomas
• Autoimune disorders
  • Alice in Wonderland syndrome
  • Acute cerebellar ataxia
  • Dermatomyositis
  • SLE
  • Rheumatoid arthritis
  • Sjögren's syndrome
  • MS

• Gianotti–Crosti syndrome
• Erythema multiforme
• Acute genital ulcers  

Infectious mononucleosis

• Fatigue, fever, inflamed throat, swollen lymph nodes in the neck, enlarged spleen, swollen liver, or rash.
• Chronic Fatigue Syndrome

• Severe hypersensitivity, Mosquito bite allergy reactions
• Mucocutaneous ulcers
• Hydroa vacciniforme

Entities

• Lymphadenopathy: Axillary, Submandibular, Symmetrical Cervical, Inguinal , Back Adenopathy

• Periorbital edema

• Uveitis
• Optic neuritis

• Nose Catarrh.

• Mouth Offensive odor. Palatal enanthem; ; at the junction of soft and hard palate. Lip ulcers. Cracked tongue.

• Pharyngitis, Tonsillitis: Sore throat. Erythematous, Swelling of tonsils. Exudation. Tonsils meet at the midline. Ulcers.
• Hepatitis: Fulminant, persistent. Hepatic failure. Cirrhosis. Hepatomegaly, Tenderness of left upper quadrant, Sensation of fullness in Abdomen, Elevated left hemidiaphragm. . Yellow face, Nausea. Vomiting.
• Splenomegaly, Splenic subcapsular bleeding. Splenic subcapsular hematoma. Splenic rupture. Discomfort. Pain; left upper quadrant ext to left scapular region; abrupt.

• Constipation. Diarrhea.
• Hemorrhoids: Rectum Pain

• Interstitial nephritis. Acute Renal failure: Hematuria; microscopic. Sediment Urine. Proteinuria
• Pericarditis.
• Myocarditis: Palpitation
• Pneumonia; interstitial, Pneumonitis; interstitial: Cough
• Acrid Leukorrhea
• Arthritis.
• Trembling of hands. Hemiplegia
• Eruptions; erythema multiforme - like, macular, , scarlatiniform,

• Urticaria.  
• Ampicillin-induced Rash.
• Ulcers:
• Petechiae esp on Palate
• Fever: afternoon, low grade, prolonged.

Neurological manifestations

• Encephalitis: Acute childhood encephalitis and remains the most common agent mimicking herpes simplex virus encephalitis, Fever (18%), Headache (66%). Seizures (48%), EEG signs (57%); Abnormal MRI findings (71%)

• Aseptic meningitis: Retro-orbital Headache;
• Transverse myelitis: Brachial plexus neuropathy.
• Guillain-Barre syndrome
• Bell’s palsy
• Cerebellar ataxia
• MRI: Basal ganglia and the striatal body, especially in the putamen and caudate nucleus