IBD, Inflammatory bowel disease: Difference between revisions

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* IBD is a group of inflammatory conditions of the colon and small intestine
* IBD is a group of inflammatory conditions of the colon and small intestine
* It causes inflammation and ulcers (sores) of digestive tract.
* [[Crohn's disease]] and [[Ulcerative Colitis|ulcerative colitis]] being the principal types.  
* [[Crohn's disease]] and [[Ulcerative Colitis|ulcerative colitis]] being the principal types.  
* Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus
* Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus
* Ulcerative colitis primarily affects the colon and the rectum.
* Ulcerative colitis primarily affects the colon and the rectum.


=== Sign / Symptoms ===
=== Sign / Symptoms ===
It may seem that Crohn's and UC are very different diseases, but both may present with similar following symptoms:


==== GI tract ====
* It may seem that Crohn's and UC are very different diseases, but both may present with similar following symptoms:
 
{| class="wikitable"
{| class="wikitable"
!
!
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|More seldom
|More seldom
|}
|}
*Abdominal pain
{| class="wikitable"
|+
!GI tract
!Extra GI
!Static
Complication
|-
|
*Abdominal pain  
* Rectal bleeding
* Mucus covered Stool
* Severe internal Cramps/ Spasms in pelvis region
*Diarrhea mixed with Bloody Mucus discharge
*Diarrhea mixed with Bloody Mucus discharge
*Weight loss, Anemia /Malabsorption /Steatorrhea (Crohn> UC )
*Weight loss, Anemia /Malabsorption /Steatorrhea(Crohn> UC)
*Fecal incontinence
*Bowel movements Increased
*Bowel movements Increased
*[[Proctitis]] (UC> Crohn)
*[[Proctitis]] (UC> Crohn):
**Urgency or rectal tenesmus + Little stool
**Urgency or rectal tenesmus + Little stool
**Tenesmus may be misinterpreted as constipation
**Tenesmus may be misinterpreted as constipation
**Fecal incontinence


*Mega colon / Colon cancer (UC> Crohn)
*Terminal ileum involvement (Crohn> UC )
*Terminal ileum involvement (Crohn> UC )  
*[[Cholangitis]] (UC> Crohn)
*[[Cholangitis]] (UC> Crohn)
*Crohn involve GI mucus membrane in patchy but deep form which ends in Stenosis/ Abcess / Fistulae but UC involvement is Shallow and Continuous.
*Crohn involve GI mucus membrane in patchy but deep form which ends in Stenosis/ Abcess / Fistulae but UC involvement is Shallow and Continuous.
 
|
====Extra GI====
*Anemia is the most prevalent extra intestinal complication
*Anemia is the most prevalent extra intestinal complication


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*[[Non Thyroidal Illness Syndrome|Non-thyroidal illness syndrome]] (NTIS)
*[[Non Thyroidal Illness Syndrome|Non-thyroidal illness syndrome]] (NTIS)
* [[Deep vein thrombosis]] (DVT)
* [[Deep vein thrombosis]] (DVT)
* [[Bronchiolitis Obliterans Organizing Pneumonia|Bronchiolitis obliterans organizing pneumonia]] (BOOP)
* [[Bronchiolitis Obliterans Organizing Pneumonia|Bronchiolitis obliterans organizing pneumonia]] (BOOP)
 
|
 
* [[Megacolon|Mega colon]]  
 
* Colon cancer
 
* (UC> Crohn)
* Abdominal pain
|}
* Diarrhea
* Rectal bleeding 
* Mucus covered Stool 
* Severe internal Cramps/ Spasms in pelvis region
* Weight loss
 
 
 
 
 
===Static complications===
*[[Megacolon|Mega colon]]
 
 
 


=== Miasms ===
=== Miasms ===
* [[CMV, Cytomegalovirus|CMV]] <ref>Wang W, Chen X, Pan J, Zhang X, Zhang L. Epstein-Barr Virus and Human Cytomegalovirus Infection in Intestinal Mucosa of Chinese Patients With Inflammatory Bowel Disease. Front Microbiol. 2022 May 31;13:915453. doi: 10.3389/fmicb.2022.915453. PMID: 35711779; PMCID: PMC9195000.</ref>: Sclerosing Cholingitis, Fistula, Uveitis, [[Colitis]]
* [[MTB, Mycobacterium tuberculosis|MTB]]: [[Ankylosing Spondylitis|Ankylosing spondylitis]] / '''[[Sacroiliitis]]''' / [[Pyoderma Gangrenosum|Pyoderma gangrenosum]], [[Arthritis]], [[Uveitis]], Cholingitis, [[Colitis]] and GI tract Ulceration
* HSV-1<ref>Marco Oliver Schunter, Thorsten Walles, Peter Fritz, Uta Meyding-Lamadé, Klaus-Peter Thon, Klaus Fellermann, Eduard Friedrich Stange, Wolfram Lamadé, Herpes simplex virus colitis complicating ulcerative colitis: A case report and brief review on superinfections, ''Journal of Crohn's and Colitis'', Volume 1, Issue 1, September 2007, Pages 41–46, <nowiki>https://doi.org/10.1016/j.crohns.2007.06.004</nowiki></ref>: [[Proctitis]] 


* [[CMV, Cytomegalovirus|CMV]] <ref>Wang W, Chen X, Pan J, Zhang X, Zhang L. Epstein-Barr Virus and Human Cytomegalovirus Infection in Intestinal Mucosa of Chinese Patients With Inflammatory Bowel Disease. Front Microbiol. 2022 May 31;13:915453. doi: 10.3389/fmicb.2022.915453. PMID: 35711779; PMCID: PMC9195000.</ref>: Sclerosing Cholingitis, Fistula, Uveitis,
=== New Idea ===
* [[MTB, Mycobacterium tuberculosis|MTB]]: [[Ankylosing Spondylitis|Ankylosing spondylitis]] / '''[[Sacroiliitis]]''' / [[Pyoderma Gangrenosum|Pyoderma gangrenosum]], [[Arthritis]], [[Uveitis]], Cholingitis
* HSV-1 <ref>Marco Oliver Schunter, Thorsten Walles, Peter Fritz, Uta Meyding-Lamadé, Klaus-Peter Thon, Klaus Fellermann, Eduard Friedrich Stange, Wolfram Lamadé, Herpes simplex virus colitis complicating ulcerative colitis: A case report and brief review on superinfections, ''Journal of Crohn's and Colitis'', Volume 1, Issue 1, September 2007, Pages 41–46, <nowiki>https://doi.org/10.1016/j.crohns.2007.06.004</nowiki></ref>
 
Note: Due to high prevalence of Bloody, painful stool in UC, I suggest HSV-1, In comparison MTB / CMV is good candidate of Crohn because of Fistula.
=== First class remedies ===
'''Diseases - CROHN'S, disease''' ''Aloe'' ars. chin. merc-c
 
==== 1.1 Merc-c ====
 
* Severe epigastric sensitivity: feeling of pain and bruising in the abdomen, especially in the area of cecum and transverse colon.
* Dysentery: Tenesmus that does not amel with defecation and has become permanent
* Hot, bloody, slimy, foul-smelling stools
* Severe cutting pains
* Severe Abdominal distention+ High sensitivity to touch
* Unceasing green bilious vomiting
 
==== 1.2 [[Orni, Ornithogalum umbellatum|Orni]] ====
 
* Feeling of struggle and twisting in the chest and stomach that started from the pyloric valve of the stomach + Flatus passing + Feeling of a ball rolling from one side of the abdomen to another
* Pain increases when food passes through the pyloric valve
 
* Coated tongue
* Anorexia + Nausea / Vomiting + Weight loss
* Stomach ulcer even with bleeding
* Coffee-ground Vomiting
* Frequent flatulence + foul-smelling flatus passing
* Pain and emptiness in the epigastrium
Ant-c
 
Podo


Lyc
* [[Crohn's disease|Crohn]] involve GI mucus membrane in patchy but deep form which ends in Stenosis/ Abcess / Fistulae but UC involvement is Shallow and Continuous.
* Does it mean UC entity is Colitis and Crohn's is Ulceration.
* If so, I can say Crohn's miasm is only MTB and UC's is CMV. If Rectum / Anus is involved, then HSV is the only miasm
* Due to high prevalence of Bloody, painful stool in UC, I suggest HSV-1, In comparison MTB / CMV is good candidate of Crohn because of Fistula.
<references />

Revision as of 03:31, 18 September 2023

Clinic

  • IBD is a group of inflammatory conditions of the colon and small intestine
  • It causes inflammation and ulcers (sores) of digestive tract.
  • Crohn's disease and ulcerative colitis being the principal types.
  • Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus
  • Ulcerative colitis primarily affects the colon and the rectum.


Sign / Symptoms

  • It may seem that Crohn's and UC are very different diseases, but both may present with similar following symptoms:
Crohn's disease Ulcerative colitis
Defecation Often porridge-like,

sometimes steatorrhea

Often mucus-like

and with blood

Tenesmus Less common More common
Fever Common Indicates severe disease
Fistulae Common Seldom
Weight loss Often More seldom
GI tract Extra GI Static

Complication

  • Abdominal pain
  • Rectal bleeding
  • Mucus covered Stool
  • Severe internal Cramps/ Spasms in pelvis region
  • Diarrhea mixed with Bloody Mucus discharge
  • Weight loss, Anemia /Malabsorption /Steatorrhea(Crohn> UC)
  • Bowel movements Increased
  • Proctitis (UC> Crohn):
    • Urgency or rectal tenesmus + Little stool
    • Tenesmus may be misinterpreted as constipation
    • Fecal incontinence
  • Terminal ileum involvement (Crohn> UC )
  • Cholangitis (UC> Crohn)
  • Crohn involve GI mucus membrane in patchy but deep form which ends in Stenosis/ Abcess / Fistulae but UC involvement is Shallow and Continuous.
  • Anemia is the most prevalent extra intestinal complication

Miasms

New Idea

  • Crohn involve GI mucus membrane in patchy but deep form which ends in Stenosis/ Abcess / Fistulae but UC involvement is Shallow and Continuous.
  • Does it mean UC entity is Colitis and Crohn's is Ulceration.
  • If so, I can say Crohn's miasm is only MTB and UC's is CMV. If Rectum / Anus is involved, then HSV is the only miasm
  • Due to high prevalence of Bloody, painful stool in UC, I suggest HSV-1, In comparison MTB / CMV is good candidate of Crohn because of Fistula.
  1. ↑ Wang W, Chen X, Pan J, Zhang X, Zhang L. Epstein-Barr Virus and Human Cytomegalovirus Infection in Intestinal Mucosa of Chinese Patients With Inflammatory Bowel Disease. Front Microbiol. 2022 May 31;13:915453. doi: 10.3389/fmicb.2022.915453. PMID: 35711779; PMCID: PMC9195000.
  2. ↑ Marco Oliver Schunter, Thorsten Walles, Peter Fritz, Uta Meyding-Lamadé, Klaus-Peter Thon, Klaus Fellermann, Eduard Friedrich Stange, Wolfram Lamadé, Herpes simplex virus colitis complicating ulcerative colitis: A case report and brief review on superinfections, Journal of Crohn's and Colitis, Volume 1, Issue 1, September 2007, Pages 41–46, https://doi.org/10.1016/j.crohns.2007.06.004
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