GSS, Gerstmann Straussler Scheinker syndrome

Clinic

• It is a prion miasm
• Typicaly includes progressive Cerebellar ataxia + Pyramidal tract signs + Pseudobulbar paralysis + myoclonus, + Absent tendon reflexes. + Dysesthesia

Parkinsonism

• Tremor
• Spasticity: Rigid muscle tone and progressive muscle stiffness and weakness, causing abnormal, writhing movements
• Bradykinesia: abnormal slowness of movement
• Myoclonus

Initial symptoms

• Paralysis: , Paraplegia / Paraparesis
• Visual disturbances/ Blindness
• Seizures
• Movements disorders such as Jerking, Myoclonus
• Deafness: Less commonly, hearing loss or deafness will develop

Athetosis

• Slow, writhing, involuntary movements

Depression

• Hypomimia or Masked faces: Reduced degree of facial expression / Emotion
• bradyphrenia

Dementia

• Cognitive dysfunction leading to bradyphrenia
• Cognition impairment such as problems in thinking, remembering, reasoning, imagining and processing thoughts which leads to Dementia
• In my research, GSS is the best remedy of Alzheimer disease, because of Memory weakness + Psychosis/ Behavioral change + Impaired Concentration + Depression

Cerebellar Ataxia

• Nystagmus
• Progressive Ataxia / Incoordination may present as unsteadiness, difficulty walking, and clumsiness /Awkwardness
• Ocular dysmetria: Difficulties judging distance or scale
• Slurred speech which progress to severe Spastic Dysarthria with UMN origin

Pyramidal signs / UMN

Corticospinal tract

• Spasticity / Spastic Paralysis
• Hyper Reflexia

Corticobulbar tract

• Paralysis of certain cranial nerves
• Pseudobulbar paralysis
  • Dysphagia
  • Dysarthria / Speech difficult
  • Emotional lability / Pseudobulbar affect
  • Hyper Reflexia
  • Spasm

Remedies

5. Phos, Agar, Caust, Lach, Con
6. Plb, Arg-n, Cocc, Calc, Sul, Stram , Nux-v