CJD, Creutzfeldt Jakob Disease: Difference between revisions
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*#Visual disturbance | *#Visual disturbance | ||
*#Movement disorders ([[Myoclonus entities|myoclonus)]] (90%) | *#Movement disorders ([[Myoclonus entities|myoclonus)]] (90%) | ||
*# | *#[[Cerebellar ataxia miasms|Cerebellar ataxia]] (80%) <ref>Tan AH, Toh TH, Low SC, Fong SL, Chong KK, Lee KW, Goh KJ, Lim SY. Chorea in Sporadic Creutzfeldt-Jakob Disease. J Mov Disord. 2018 Sep;11(3):149-151. doi: 10.14802/jmd.18017. Epub 2018 Aug 9. PMID: 30086616; PMCID: PMC6182307.</ref> | ||
* Nonspecific / Prodromal syndrome of fatigue Sleeping/ Eating disorders (33%) | * Nonspecific / Prodromal syndrome of fatigue Sleeping/ Eating disorders (33%) | ||
* Cognitive symptoms such as Memory loss / Confusion or Behavioral changes / Personality changes / Hallucinations (33%) | * Cognitive symptoms such as Memory loss / Confusion or Behavioral changes / Personality changes / Hallucinations (33%) | ||
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=== Entities === | === Entities === | ||
* ''[[Cerebellar ataxia miasms|Cerebellar Ataxia]]: Incoordination'' | * ''[[Cerebellar ataxia miasms|Cerebellar Ataxia]]: Incoordination, [[Dysarthria]] , Difficult Speech, Nystagmus,'' Gait abnormalities | ||
* [[Brainstem|Brain-stem]] | * [[Brainstem|Brain-stem]]: Dysphagia | ||
* [[Pyramidalism|Pyramidal]] signs / [[Upper Motot Neuron|UMN]]: | |||
** ''Myoclonic Jerking, Myoclonus'' | |||
** ''[[Hyper reflexia|Hyperreflexia]]'' | |||
* [[Medulla oblongata|Medulla oblangata]] esp dorsal motor nucleus of vagus and other medullary nuclei <ref>Iacono D, Ferrari S, Gelati M, Zanusso G, Mariotto S, Monaco S. Sporadic Creutzfeldt-Jakob Disease: Prion Pathology in Medulla Oblongata-Possible Routes of Infection and Host Susceptibility. Biomed Res Int. 2015;2015:396791. doi: 10.1155/2015/396791. Epub 2015 Sep 17. PMID: 26457299; PMCID: PMC4589575.</ref> | * [[Medulla oblongata|Medulla oblangata]] esp dorsal motor nucleus of vagus and other medullary nuclei <ref>Iacono D, Ferrari S, Gelati M, Zanusso G, Mariotto S, Monaco S. Sporadic Creutzfeldt-Jakob Disease: Prion Pathology in Medulla Oblongata-Possible Routes of Infection and Host Susceptibility. Biomed Res Int. 2015;2015:396791. doi: 10.1155/2015/396791. Epub 2015 Sep 17. PMID: 26457299; PMCID: PMC4589575.</ref> | ||
* ''[[ | * ''[[Psychosis]]: Behavioral change'' | ||
* ''Cortical Blindness:'' ''Visual Agnosia,'' ''Visual field deficits,'' ''Blindness'' | * ''Cortical Blindness:'' ''Visual [[Agnosia]],'' ''Visual field deficits,'' ''Blindness'' | ||
*[[Extrapyramidal signs|Extrapyramidal]] <ref>Misdiagnosis of an Atypical Creutzfeldt-Jakob Disease: Analysis of One Case in China and Review of the Literature, Mengqi Zhanga1 , Zigao Wangb2 , Lijie Duana1 and Hengbing Zua1 * 1 Department of Neurology, Jinshan Hospital, Fudan University, China</ref> | *[[Extrapyramidal signs|Extrapyramidal]] <ref>Misdiagnosis of an Atypical Creutzfeldt-Jakob Disease: Analysis of One Case in China and Review of the Literature, Mengqi Zhanga1 , Zigao Wangb2 , Lijie Duana1 and Hengbing Zua1 * 1 Department of Neurology, Jinshan Hospital, Fudan University, China</ref> | ||
** [[Dystonia miasms|Dystonia]]: ''[[Rigidity miasms|Rigidity]]'' | ** [[Dystonia miasms|Dystonia]]: ''[[Rigidity miasms|Rigidity]]'' | ||
** [[Parkinsonism]] ([[Bradykinesia miasms|Bradykinesia]], ''Rigidity, [[Tremor miasms|Tremor]])'' | ** [[Parkinsonism]] ([[Bradykinesia miasms|Bradykinesia]], ''[[Rigidity miasms|Rigidity]], [[Tremor miasms|Tremor]])'' | ||
* Involuntary movement / [[Frontal lobe epilepsy|Frontal Lobe Seizure]] (Focal / Partial seizure) | * Involuntary movement / [[Frontal lobe epilepsy|Frontal Lobe Seizure]] (Focal / Partial [[seizure]]) | ||
''Paresthesia'' | |||
''Muscular Atrophy'' | ''Muscular Atrophy'' | ||
| Line 48: | Line 45: | ||
''Fasciculation'' | ''Fasciculation'' | ||
''Muscular Spasm'' | |||
=== Related disease === | |||
* [[Dementia]]: ''Memory weakness,'' ''Disorientation'' | * [[Dementia]]: ''Memory weakness,'' ''Disorientation'' | ||
* | * [[Parkinson disease]] | ||
* Sleep pathology is common including | |||
** [[Restless legs syndrome|Restless legs symptoms]] | |||
** Sleep-disordered breathing | |||
** [[Parasomnia|Parasomnias]] (REM sleep without atonia, [[REM Related parasomnias|REM sleep behavior disorder]], [[Periodic limb movement disorder|Periodic limb movements]]) | |||
=== Dysphagia === | |||
As the disease process advances, destruction of the cerebral architecture in sensory, motor, and associated areas can lead to oropharyngeal dysphagia. <ref>Salhab, Joseph DO1; Sharma, Saras DO2; Mohamadameen, Ranje DO2; Valladares, Michael DO2; Sobrado, Javier MD2; Mohan, Karthik MD3. Management of Dysphagia in a Patient with Creutzfeldt-Jakob Disease: 1230. American Journal of Gastroenterology 110():p S542, October 2015. </ref> | As the disease process advances, destruction of the cerebral architecture in sensory, motor, and associated areas can lead to oropharyngeal dysphagia. <ref>Salhab, Joseph DO1; Sharma, Saras DO2; Mohamadameen, Ranje DO2; Valladares, Michael DO2; Sobrado, Javier MD2; Mohan, Karthik MD3. Management of Dysphagia in a Patient with Creutzfeldt-Jakob Disease: 1230. American Journal of Gastroenterology 110():p S542, October 2015. </ref> | ||
| Line 74: | Line 65: | ||
# | # | ||
#'''[[Agar, Agaricus Muscarius|AGAR]], [[Nux-m, Nux Moschata|NUX-M]]''' | #'''[[Agar, Agaricus Muscarius|AGAR]], [[Nux-m, Nux Moschata|NUX-M]]''' | ||
# Cupr, Caust, Merc, Plb, Bell, Phos, Stram | # Cupr, Caust, Merc, Plb, Bell, Phos, Stram | ||
# Sil, Ars, Sul | # Sil, Ars, Sul | ||
Revision as of 22:28, 26 March 2023
Clinic
- It is the most important Prion miasm.
- A rare neurodegenerative disease that is clinically characterized by
- Rapidly progressive dementia
- Visual disturbance
- Movement disorders (myoclonus) (90%)
- Cerebellar ataxia (80%) [1]
- Nonspecific / Prodromal syndrome of fatigue Sleeping/ Eating disorders (33%)
- Cognitive symptoms such as Memory loss / Confusion or Behavioral changes / Personality changes / Hallucinations (33%)
- Focal neurological signs (33%) such as
- Ataxia
- Dysarthria
- Visual loss
- Hemiparesis
- Almost all patients enter a phase of Akinetic mutism before death.
- Although chorea is commonly observed in variant CJD (vCJD= NVCJD), it is considered a rare occurrence in sporadic CJD (sCJD).
Entities
- Cerebellar Ataxia: Incoordination, Dysarthria , Difficult Speech, Nystagmus, Gait abnormalities
- Brain-stem: Dysphagia
- Pyramidal signs / UMN:
- Myoclonic Jerking, Myoclonus
- Hyperreflexia
- Medulla oblangata esp dorsal motor nucleus of vagus and other medullary nuclei [2]
- Psychosis: Behavioral change
- Cortical Blindness: Visual Agnosia, Visual field deficits, Blindness
- Involuntary movement / Frontal Lobe Seizure (Focal / Partial seizure)
Paresthesia
Muscular Atrophy
Fasciculation
Muscular Spasm
Related disease
- Dementia: Memory weakness, Disorientation
- Parkinson disease
- Sleep pathology is common including
- Restless legs symptoms
- Sleep-disordered breathing
- Parasomnias (REM sleep without atonia, REM sleep behavior disorder, Periodic limb movements)
Dysphagia
As the disease process advances, destruction of the cerebral architecture in sensory, motor, and associated areas can lead to oropharyngeal dysphagia. [4]
Remedies
- ↑ Tan AH, Toh TH, Low SC, Fong SL, Chong KK, Lee KW, Goh KJ, Lim SY. Chorea in Sporadic Creutzfeldt-Jakob Disease. J Mov Disord. 2018 Sep;11(3):149-151. doi: 10.14802/jmd.18017. Epub 2018 Aug 9. PMID: 30086616; PMCID: PMC6182307.
- ↑ Iacono D, Ferrari S, Gelati M, Zanusso G, Mariotto S, Monaco S. Sporadic Creutzfeldt-Jakob Disease: Prion Pathology in Medulla Oblongata-Possible Routes of Infection and Host Susceptibility. Biomed Res Int. 2015;2015:396791. doi: 10.1155/2015/396791. Epub 2015 Sep 17. PMID: 26457299; PMCID: PMC4589575.
- ↑ Misdiagnosis of an Atypical Creutzfeldt-Jakob Disease: Analysis of One Case in China and Review of the Literature, Mengqi Zhanga1 , Zigao Wangb2 , Lijie Duana1 and Hengbing Zua1 * 1 Department of Neurology, Jinshan Hospital, Fudan University, China
- ↑ Salhab, Joseph DO1; Sharma, Saras DO2; Mohamadameen, Ranje DO2; Valladares, Michael DO2; Sobrado, Javier MD2; Mohan, Karthik MD3. Management of Dysphagia in a Patient with Creutzfeldt-Jakob Disease: 1230. American Journal of Gastroenterology 110():p S542, October 2015.