HSV-1, Herpes Simplex Virus: Difference between revisions

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=== Clinic ===
* HSV-1 is a [[Viral miasms|viral miasm]], belongs to [[Herpes viruses]]
* It is very invasive
* It involve mucus membrane and neural endings which cause burning pain.
{| class="wikitable"
|+
!
=== Entities ===
=== Entities ===
!
=== Sign / Symptoms ===
!
=== Disease ===
|-
|[[Herpetic eruption|Herpetic rash]]
|Vesicular eruptions
|
*[[Eczema]]
* [[Skin cracks remedies|Skin cracks]]
* Crusted rashes
* Itching
* Small pimples
* White sores of esophagus, anus
|-
|[[Cellulitis]]
|
* Redness
* Swelling
* Pain / Tenderness
* Esp female genital skin and fingers.
|Wounds esp


* Herpetic rash, vesicular
* Female
* Eczema, skin cracks, crusted rashes, itching, small pimples
* Mouth, Tongue,  
* Cellulite, urticaria: Redness + Swelling + Pain + Tenderness esp female genital skin and fingers.
|-
* Myelitis esp [[Transverse myelitis miasms|transverse myelitis]] (Weakness + Paralysis + Decreased deep reflexes of the limbs):
|[[Myelitis]]
|
* Weakness  
* Paralysis
* Decreased deep reflexes of the limbs, Esp
** Face
** Face
** Anus, male genitalia, Bulbocavernous
** Anus, male genitalia, Bulbocavernous
** Extremities especially lower limbs
** Extremities esp lower limbs
** Muscles, back muscles
** Muscles, Back muscles
 
|[[Transverse myelitis]]
* Neuropathy, Neuritis (Limbs, Fingers, buttocks, around the anus, lower back and sacrum and mouth) Radiculopathy, esp in the sacrum area
|-
* [[Neurogenic bladder entities|Neurogenic Bladder]] : Large bladder + Dysuria + Urinary frequency / Incontinence + Urinary retention + Nocturnal enuresis
|[[Neuropathy]] / Neuritis
 
|
* Wounds: (Female, Mouth, Tongue, White sores of esophagus, anus)
* Limbs, Fingers, buttocks, around the anus, lower back and sacrum and mouth   
 
* [[Radiculopathy]] esp in the sacrum area
* Conjunctivitis, Keratitis, Chemosis: (Photophobia, Eye pain, Corneal dendritic lesions)
|
* [[Retinitis miasms|Retinitis]], chorioretinitis, retinal necrosis (Blurred vision+ Blindness)
|-
* Gingivitis, stomatitis (Necrosis + Mouth pain + the patient is unable to drink or eat)
|[[Neurogenic bladder|Neurogenic Bladder]]
* Pharyngitis (Exudate / Catarrh + Odynophagia + Pseudomembrane)
|
 
* Large bladder / Urinary retention
* Proctitis (Tenesmus + Pain = Necrosis + Constipation = Anal discharge
* Dysuria  
 
* Urinary frequency / [[Urinary incontinence|Incontinence]]
* Urethritis (Mucoid urethral secretions + Dysuria +Urinary frequency)
* [[Enuresis remedies|Nocturnal enuresis]]
* Salpingitis, Endometritis (Leukourrhea + Painful menses)
|
|-
|
* [[Conjunctivitis]]
* [[Keratitis]]
* [[Chemosis]]
|
* Photophobia
* Eye pain
|Corneal dendritic lesions
|-
|
* [[Retinitis]]
* [[Chorioretinitis remedies|Chorioretinitis]]
|
* Blurred vision
* Blindness
|Retinal necrosis
|-
|
* [[Gingivitis remedies|Gingivitis]]
* [[Aphthous stomatitis|Stomatitis]]
* [[Chelitis]]
|
* Necrosis
* Mouth pain
* Unablility to drink or eat
|
|-
|[[Pharyngitis]]
|
* Exudate / Catarrh
* Odynophagia  
|Pseudomembrane
|-
|[[Proctitis]]
|
* Tenesmus / Pain  
* Necrosis  
* Constipation  
* Anal discharge
|
|-
|[[Urethritis]]
|
* Mucoid urethral secretions  
* Dysuria  
* Urination frequency
|
|-
|
* [[Salpingitis]]
* [[Endometritis]]
|
* [[PID, Pelvic inflammatory disease|Leukourrhea]]
* Painful menses
|
|-
|[[Prostatitis]]
|
* Itching
* Pain
|
|-
|[[Impotency]]
|Male Infertility
|
|-
|
* [[Pneumonia]]
* [[Interstitial pneumonitis]]
* [[Tracheitis]]
* [[Tracheitis|Bronchitis]]
|
*
*
|
* ARDS
* Local necrosis,
|-
|
* [[Meningitis]]
* E[[Encephalitis|ncephalitis]]
|
* Terrible dreams
* Sad, crying
|[[HSV Encephalitis|HSV encephalitis]] (HSE)
|-
|[[Myositis ossificans|Myositis]]
|
* Myoglobinuria
* Myalgia agg with physical activity
|
|-
|[[Thrombocytopenia]]
|
|
|-
|[[Hepatitis]]
|
|
|-
|
|
* Adrenal lesion
* [[Adrenal insufficiency]]
|
|-
|[[Lymphadenitis]]
|
* Lymphadenopathy: Esp Neck, Axillary, Limbs, Elbow, Inguinal
* Painful
|
|-
|[[Arthritis]]
|Esp single-joint type
|
|-
|[[Urticaria]]
|
|
|}
* IUGR (Miscarriage + Itching + Blisters + Pain + Discharge
* IUGR (Miscarriage + Itching + Blisters + Pain + Discharge
* Male Infertility, prostatitis (Itching + Pain)
* Pneumonia, interstitial tissue pneumonia, tracheobronchitis, pneumonitis: local necrosis, ARDS
* Meningitis, encephalitis: terrible dreams, sad, crying
* Myositis (Myoglobinuria, Myalgia agg with physical activity)
* Thrombocytopenia
* Hepatitis
* Adrenal lesion, [[Adrenal insufficiency]]
Lymphadenitis and lymphadenopathy: neck, axillary, limbs, especially elbow, painful inguinal lymphadenopathy
Arthritis, especially of the single-joint type
[[Chelitis remedies|Chelitis]]
[[Gingivitis remedies|Gingivitis]]
[[Herpetic eruption remedies|Herpetic eruption]]
[[Keratitis remedies|Keratitis]]
[[Proctitis remedies|Proctitis]]
=== HSV encephalitis (HSE) ===
* '''ٍ'''Encephalitis due to HSV-1 in 500,000 individuals per year. Annual incidence of HSE is 2 -4 cases per 1 million population.
* 90% of cases of HSE are caused by HSV-1, the rest of cases are due to HSV-2.
* Most individuals show a decrease in their level of consciousness and an altered mental state presenting as confusion.
* Patients typically have a fever and may have seizures. EEG first showing abnormalities in one temporal lobe, which spread to the other temporal lobe 7–10 days later.
* HSE can serve as a trigger of [[NMDR encephalitis]].
* The virus lies dormant in the ganglion of the '''trigeminal cranial nerve''', but the reason for reactivation, and its pathway to gain access to the brain, remains unclear, though changes in the immune system caused by stress clearly play a role in animal models of the disease.
* The '''olfactory nerve''' may also be involved in HSE, which may explain its predilection for the temporal lobes of the brain, as the olfactory nerve sends branches there
* Recently included 420 adult patients with schizophrenia or bipolar spectrum and 481 healthy controls. Circulating HSV1 IgG concentrations were measured with immunoassays. We measured the total grey matter volume, cortical, subcortical, cerebellar and regional cortical volumes. The results of this cross-sectional study indicate that HSV1 may be an environmental factor associated with brain structural abnormalities and cognitive impairment in severe mental illnesses such as Schizophrenia and bipolar disorder. <ref>Andreou, D., Jørgensen, K.N., Nerland, S. ''et al.'' Herpes simplex virus 1 infection on grey matter and general intelligence in severe mental illness. ''Transl Psychiatry'' '''12''', 276 (2022). <nowiki>https://doi.org/10.1038/s41398-022-02044-3</nowiki></ref>
* HSV-1 is the most common cause of sporadic necrotizing encephalitis in the United States, with a mortality rate of 30 -70 %, and leaves various neurologic sequelae in the survivors. HSV-2 has been recognized as an etiologic agent in fatal infections in neonates and a mild meningitis in adults, but its role in encephalitis in adults is less well known. We suggest that some cases of acute psychosis may, like in our case, represent HSV-2 encephalitis.<ref>[https://wikihomeopathy.com/index.php/Herpes%20simplex%20type%202%20virus%20encephalitis%20presenting%20as%20psychosis,%20VOLUME%2073,%20ISSUE%203,%20P445-448,%20SEPTEMBER%2001,%201982 Herpes simplex type 2 virus encephalitis presenting as psychosis, VOLUME 73, ISSUE 3, P445-448, SEPTEMBER 01, 1982]</ref>
* HSE as a cause of '''psychosis''' is rare, affecting about 1 per 200,000 cases per year. It is suggested that herpes infection like other environmental stressors causes psychosis through inhibition of NMDA receptor and subsequent microglia activation in the hippocampus. <ref>Klein H. C., Doorduin J., de Witte L., de Vries E. F. ''Immunology and Psychiatry''. Vol. 8. Switzerland: Springer; 2015. Microglia activation, herpes infection, and NMDA receptor inhibition: common pathways to psychosis? pp. 243–254. (Current Topics in Neurotoxicity).</ref>
* Common symptoms of HSE  include headaches, fevers, drowsiness, hyperactivity, and/or general weakness. The disorder may have some symptoms similar to those associated with meningitis, such as a stiff neck, altered reflexes, confusion, and/or speech abnormalities. Skin lesions usually are not found in association with herpes simplex encephalitis. <ref>NORD</ref>
* HSV-1 encephalitis is the most common cause of sporadic fatal encephalitis worldwide. The clinical syndrome is often characterized by the rapid onset of fever, headache, seizures, focal neurologic signs, and impaired consciousness. <ref>Hanley DF, Johnson RT, Whitley RJ. Yes, brain biopsy should be a prerequisite for herpes simplex encephalitis treatment. Arch Neurol 1987; 44:1289.</ref>
* Seizures during the acute phase of HSE are the main risk for the development of postencephalitic epilepsy <ref>Sellner J, Trinka E. Seizures and epilepsy in herpes simplex virus encephalitis: current concepts and future directions of pathogenesis and management. J Neurol. 2012 Oct;259(10):2019-30. doi: 10.1007/s00415-012-6494-6. Epub 2012 Apr 18. PMID: 22527234.</ref>
* Persistent infection with HSV and other brain infections is consistently associated with cognitive impairment. These infections can also affect sleep. Thus, sleep abnormalities could explain the cognitive dysfunction.<ref>Meshreky KM, Wood J, Chowdari KV, Hall MH, Wilckens KA, Yolken R, Buysse DJ, Nimgaonkar VL. Infection with Herpes Simplex virus type 1 (HSV-1) and sleep: The dog that did not bark. Psychiatry Res. 2019 Oct;280:112502. doi: 10.1016/j.psychres.2019.112502. Epub 2019 Jul 31. PMID: 31382180; PMCID: PMC7265549.</ref>


=== [[Parkinsonism]] ===
=== [[Parkinsonism]] ===
Recently a relation between Parkinsonism and HSV infection is found through a population-based case-control study of incident Parkinson’s disease. <ref>Camacho-Soto A, Faust I, Racette BA, Clifford DB, Checkoway H, Searles Nielsen S. Herpesvirus Infections and Risk of Parkinson's Disease. Neurodegener Dis. 2020;20(2-3):97-103. doi: 10.1159/000512874. Epub 2021 Jan 18. PMID: 33461199; PMCID: PMC8552529.</ref>
Recently a relation between Parkinsonism and HSV infection is found through a population-based case-control study of incident Parkinson’s disease. <ref>Camacho-Soto A, Faust I, Racette BA, Clifford DB, Checkoway H, Searles Nielsen S. Herpesvirus Infections and Risk of Parkinson's Disease. Neurodegener Dis. 2020;20(2-3):97-103. doi: 10.1159/000512874. Epub 2021 Jan 18. PMID: 33461199; PMCID: PMC8552529.</ref>


=== HSV-1 [[colitis]] ===
=== HSV-1 [[colitis]] ===


* Symptoms of HSV colitis are not specific and do not differ considerably from colitis caused by other agents. Watery diarrhoea with addition of blood, crampy abdominal pain, fever, arthralgia, nausea, loss of appetite and loss of weight can be found. <ref>Dray, Xavier, et al. "Herpes simplex virus type 1 colitis in a patient with common variable immunodeficiency syndrome." ''European journal of gastroenterology & hepatology'' 18.5 (2006): 541-544.</ref>
* Symptoms of HSV colitis are not specific and do not differ considerably from colitis caused by other agents.  
 
* Watery / Bloody diarrhea, crampy abdominal pain, fever, arthralgia, nausea, loss of appetite and loss of weight can be found. <ref>Dray, Xavier, et al. "Herpes simplex virus type 1 colitis in a patient with common variable immunodeficiency syndrome." ''European journal of gastroenterology & hepatology'' 18.5 (2006): 541-544.</ref>
 




=== Remedies ===
=== Remedies ===


# '''NAT-M,     ARS'''
# '''[[Nat-m, Natrium muriaticum|NAT-M]], [[Ars, Arsenicum Album|ARS]]'''
# '''Hep'''
# '''[[Hep, Hepar Sulphur|Hep]]'''
# Borx,     Con, Arum-t, Rhus-t, Nit-ac, Mez, Kreos, Sul, Phos, Sep
# Borx, Con, Arum-t, [[Rhus-t, Rhus toxicodendron|Rhus-t]], Nit-ac, Mez, Kreos, Sul, Phos, Sep
# Am-c, Aeth, Anac, Sul-ac, Canth, Graph, Hydr,     Iris, Lach, [[Sars, Sarsaparilla officinalis|Sars]], Nat-c, Merc
# Am-c, Aeth, Anac, Sul-ac, Canth, Graph, Hydr, Iris, Lach, [[Sars, Sarsaparilla officinalis|Sars]], Nat-c, Merc






<references />
<references />

Latest revision as of 08:43, 22 November 2023

Clinic

  • HSV-1 is a viral miasm, belongs to Herpes viruses
  • It is very invasive
  • It involve mucus membrane and neural endings which cause burning pain.

Entities

Sign / Symptoms

Disease

Herpetic rash Vesicular eruptions
  • Eczema
  • Skin cracks
  • Crusted rashes
  • Itching
  • Small pimples
  • White sores of esophagus, anus
Cellulitis
  • Redness
  • Swelling
  • Pain / Tenderness
  • Esp female genital skin and fingers.
 Wounds esp
  • Female
  • Mouth, Tongue,
Myelitis
  • Weakness
  • Paralysis
  • Decreased deep reflexes of the limbs, Esp
    • Face
    • Anus, male genitalia, Bulbocavernous
    • Extremities esp lower limbs
    • Muscles, Back muscles
 Transverse myelitis
Neuropathy / Neuritis
  • Limbs, Fingers, buttocks, around the anus, lower back and sacrum and mouth
  • Radiculopathy esp in the sacrum area
Neurogenic Bladder
  • Photophobia
  • Eye pain
 Corneal dendritic lesions
  • Blurred vision
  • Blindness
 Retinal necrosis
  • Necrosis
  • Mouth pain
  • Unablility to drink or eat
Pharyngitis
  • Exudate / Catarrh
  • Odynophagia
 Pseudomembrane
Proctitis
  • Tenesmus / Pain
  • Necrosis
  • Constipation
  • Anal discharge
Urethritis
  • Mucoid urethral secretions
  • Dysuria
  • Urination frequency
Prostatitis
  • Itching
  • Pain
Impotency Male Infertility
  • ARDS
  • Local necrosis,
  • Terrible dreams
  • Sad, crying
 HSV encephalitis (HSE)
Myositis
  • Myoglobinuria
  • Myalgia agg with physical activity
Thrombocytopenia
Hepatitis
Lymphadenitis
  • Lymphadenopathy: Esp Neck, Axillary, Limbs, Elbow, Inguinal
  • Painful
Arthritis Esp single-joint type
Urticaria
  • IUGR (Miscarriage + Itching + Blisters + Pain + Discharge

Parkinsonism

Recently a relation between Parkinsonism and HSV infection is found through a population-based case-control study of incident Parkinson’s disease. [1]


HSV-1 colitis

  • Symptoms of HSV colitis are not specific and do not differ considerably from colitis caused by other agents.
  • Watery / Bloody diarrhea, crampy abdominal pain, fever, arthralgia, nausea, loss of appetite and loss of weight can be found. [2]


Remedies

  1. NAT-M, ARS
  2. Hep
  3. Borx, Con, Arum-t, Rhus-t, Nit-ac, Mez, Kreos, Sul, Phos, Sep
  4. Am-c, Aeth, Anac, Sul-ac, Canth, Graph, Hydr, Iris, Lach, Sars, Nat-c, Merc


  1. ↑ Camacho-Soto A, Faust I, Racette BA, Clifford DB, Checkoway H, Searles Nielsen S. Herpesvirus Infections and Risk of Parkinson's Disease. Neurodegener Dis. 2020;20(2-3):97-103. doi: 10.1159/000512874. Epub 2021 Jan 18. PMID: 33461199; PMCID: PMC8552529.
  2. ↑ Dray, Xavier, et al. "Herpes simplex virus type 1 colitis in a patient with common variable immunodeficiency syndrome." European journal of gastroenterology & hepatology 18.5 (2006): 541-544.
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