Autoimmune Polyendocrine Syndrome: Difference between revisions

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There are two distinct types APS-1 and APS-2
=== Types ===
 
* There are two distinct types APS-1 and APS-2
* APS also named PAS


== APS-1 ==
== APS-1 ==
=== Clinic ===
=== Clinic ===


* APS-1 is a subtype of autoimmune polyendocrine syndrome
* APS-1 causes the dysfunction of multiple endocrine glands due to autoimmunity.
* It causes the dysfunction of multiple endocrine glands due to autoimmunity.  
* It is an inherited in autosomal recessive fashion
* It is an inherited in autosomal recessive fashion


Line 11: Line 13:
=== Signs and symptoms ===
=== Signs and symptoms ===


* Chronic mucocutaneous candidiasis.
* Chronic mucocutaneous candidiasis
* Hypoparathyroidism.
* Hypoparathyroidism
* Addison's disease.
* [[Addison's disease]]
* Ectodermal dystrophy (skin, dental enamel, and nails).
* Ectodermal dystrophy (Skin, Dental enamel, and Nails)
 
 


APS-1 may also cause:
APS-1 may also cause:


* Autoimmune hepatitis.
* Autoimmune [[hepatitis]]
* Hypogonadism.
* [[Hypogonadism]]
* Vitiligo.
* [[Vitiligo]]
* Alopecia.
* [[Alopecia]]
* Malabsorption.
* Malabsorption
* Pernicious anemia.
* [[Pernicious anemia]]
* Cataract.
* [[Cataract]]
* Cerebellar ataxia.
* [[Cerebellar ataxia]]
 


== APS-2 ==


===Clinic===
*APS-2 a form of autoimmune polyendocrine syndrome also known as PAS II
*It is the most common form of the polyglandular failure syndromes.
*PAS II is defined as the association between autoimmune [https://wikihomeopathy.com/index.php/Addison's_disease Addison's disease] and either autoimmune thyroid disease, type 1 diabetes, or both.
*It is heterogeneous and has not been linked to one gene.
*APS-II affects women to a greater degree than men.
===Signs and symptoms===
*[https://wikihomeopathy.com/index.php/Hashimoto_thyroiditis Hashimoto thyroiditis]: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
*Low blood pressure
*Hypoparathyroidism
*Myalgia
*Graves' disease
*Anaemia
*Hypogonadism
*Diabetes mellitus


=== Entities / Miasms ===
=== APS-1 Entity / Miasm ===
{| class="wikitable"
{| class="wikitable"
!
!
!HSV
!EBV
!EBV
!MTB
!CMV
!HCV
!MMP
!MMP
!B19
!CXB
!HCV
!HSV
!RBL
|-
|-
|[https://wikihomeopathy.com/index.php/Hashimoto_thyroiditis Hashimoto thyroiditis]
|[[Hepatitis]]
| ++
| +++
|
| +++
|<nowiki>+++</nowiki>
| +++
| +
| +++
|<nowiki>+</nowiki>
| +++
| +++
| +
| +
|-
|-
|[https://wikihomeopathy.com/index.php/Adrenal%20insufficiency Adrenal insufficiency]
|Infertitiy
|
|
|
|
|
|
|
| +++
|
| +++
|
| ++
|
|-
|-
|Diabetes Insulin dependent
|[[Vitiligo]]
| +++
| +++
|
|
| +++
| +++
|
|
| +++
|
|
|-
|[[Atrophic Gastritis entities|Atrophic Gastritis]]
|
|
| +++
| +++
|-
|Female, Infertility / Oophoritis
|
|
| +++
| +++
| +++
|
|
|-
|[[Cataract]]
|
|
|
|
| +
|
|
|
|
|-
|-
|Anemia
|[[Cerebellar ataxia]]
| +++
| +++
| +++
| +++
|
|
|
| +++
|-
|[[Autoimmune adrenalitis]]
| ++
| +
| +++
| +++
|<nowiki>+++</nowiki>
|
|
|
|
| +++
|-
|-
|[[Alopecia]]
|
|
|
|
|
|
| +
|
|
|}
== APS-2 ==
===Clinic===
*It is the most common form
*It is heterogeneous and has not been linked to one gene.
*It affects women to a greater degree than men.
===Signs / Symptoms===
*[[Hashimoto thyroiditis]]: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
*Low blood pressure
*Hypoparathyroidism
*Myalgia
*Graves' disease
*Anemia
*[[Hypogonadism]]
*Diabetes mellitus
=== APS-2 Entities / Miasms ===
{| class="wikitable"
!
!MTB
!MMP
!EBV
!HCV
|-
|Infertility
| +++
| +++
|
|
|
|
|-
|[[Hashimoto thyroiditis]]
| +++
| +++
| +++
| +++
|-
|Anemia
| +++
|
| +++
| +++
|-
|Diabetes mellitus, juvenile
|
|
| +++
|
|
|
|
|}
|}
=== Note ===
It seems that APS is a [[Cluster Of Entities|COE]].

Latest revision as of 08:22, 2 May 2023

Types

  • There are two distinct types APS-1 and APS-2
  • APS also named PAS

APS-1

Clinic

  • APS-1 causes the dysfunction of multiple endocrine glands due to autoimmunity.
  • It is an inherited in autosomal recessive fashion


Signs and symptoms

  • Chronic mucocutaneous candidiasis
  • Hypoparathyroidism
  • Addison's disease
  • Ectodermal dystrophy (Skin, Dental enamel, and Nails)


APS-1 may also cause:


APS-1 Entity / Miasm

HSV EBV CMV HCV MMP
Hepatitis +++ +++ +++ +++ +++
Infertitiy +++ +++
Vitiligo +++ +++
Atrophic Gastritis +++ +++
Cataract +
Cerebellar ataxia +++ +++ +++
Autoimmune adrenalitis ++ + +++
Alopecia +


APS-2

Clinic

  • It is the most common form
  • It is heterogeneous and has not been linked to one gene.
  • It affects women to a greater degree than men.


Signs / Symptoms

  • Hashimoto thyroiditis: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
  • Low blood pressure
  • Hypoparathyroidism
  • Myalgia
  • Graves' disease
  • Anemia
  • Hypogonadism
  • Diabetes mellitus


APS-2 Entities / Miasms

MTB MMP EBV HCV
Infertility +++ +++
Hashimoto thyroiditis +++ +++ +++ +++
Anemia +++ +++ +++
Diabetes mellitus, juvenile +++


Note

It seems that APS is a COE.

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