Autoimmune Polyendocrine Syndrome

Types

• There are two distinct types APS-1 and APS-2
• APS also named PAS

APS-1

Clinic

• APS-1 causes the dysfunction of multiple endocrine glands due to autoimmunity.
• It is an inherited in autosomal recessive fashion

Signs and symptoms

• Chronic mucocutaneous candidiasis
• Hypoparathyroidism
• Addison's disease
• Ectodermal dystrophy (Skin, Dental enamel, and Nails)

APS-1 may also cause:

• Autoimmune hepatitis
• Hypogonadism
• Vitiligo
• Alopecia
• Malabsorption
• Pernicious anemia
• Cataract
• Cerebellar ataxia

APS-1 Entity / Miasm

	HSV	EBV	CMV	HCV	MMP
Hepatitis	+++	+++	+++	+++	+++
Infertitiy				+++	+++
Vitiligo	+++		+++
Atrophic Gastritis		+++		+++
Cataract			+
Cerebellar ataxia	+++	+++			+++
Autoimmune adrenalitis	++	+	+++
Alopecia				+

APS-2

Clinic

• It is the most common form
• It is heterogeneous and has not been linked to one gene.
• It affects women to a greater degree than men.

Signs / Symptoms

• Hashimoto thyroiditis: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
• Low blood pressure
• Hypoparathyroidism
• Myalgia
• Graves' disease
• Anemia
• Hypogonadism
• Diabetes mellitus

APS-2 Entities / Miasms

	MTB	MMP	EBV	HCV
Infertility	+++	+++
Hashimoto thyroiditis	+++	+++	+++	+++
Anemia	+++		+++	+++
Diabetes mellitus, juvenile		+++

Note

It seems that APS is a COE.