Autoimmune Polyendocrine Syndrome: Difference between revisions

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=== Clinic ===
=== Clinic ===


* APS-1causes the dysfunction of multiple endocrine glands due to autoimmunity.
* APS-1 causes the dysfunction of multiple endocrine glands due to autoimmunity.
* It is an inherited in autosomal recessive fashion
* It is an inherited in autosomal recessive fashion


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* Hypoparathyroidism
* Hypoparathyroidism
* [[Addison's disease]]
* [[Addison's disease]]
* Ectodermal dystrophy (skin, dental enamel, and nails)
* Ectodermal dystrophy (Skin, Dental enamel, and Nails)




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* [[Pernicious anemia]]
* [[Pernicious anemia]]
* [[Cataract]]
* [[Cataract]]
* [[Cerebellar ataxia miasms|Cerebellar ataxia]]
* [[Cerebellar ataxia]]




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{| class="wikitable"
{| class="wikitable"
!
!
!HCV
!HSV
!HSV
!MMP
!EBV
!EBV
!CMV
!CMV
!HCV
!MMP
|-
|-
|[[Hepatitis]]
|[[Hepatitis]]
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|-
|-
|Infertitiy
|Infertitiy
| +++
|
|
| +++
|
|
|
|
| +++
| +++
|-
|-
|[[Vitiligo]]
|[[Vitiligo]]
| +++
|
|
| +++
| +++
|
|
|
|
| +++
|-
|-
|[[Atrophic Gastritis entities|Atrophic Gastritis]]
|[[Atrophic Gastritis entities|Atrophic Gastritis]]
|
| +++
| +++
|
|
|
| +++
| +++
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|
|
|
|
| +
|
|
|
|
|-
|[[Cerebellar ataxia]]
| +++
| +++
|
|
|-
|[[Cerebellar ataxia miasms|Cerebellar ataxia]]
|
|
| +++
| +++
|-
|[[Autoimmune adrenalitis]]
| ++
| +
| +++
| +++
| +++
|
|
|
|-
|-
|[[Autoimmune adrenalitis]]  
|[[Alopecia]]
|
|
|
| ++
|
|
| +
| +
| +++
|
|}
|}


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*It affects women to a greater degree than men.
*It affects women to a greater degree than men.


===Signs and symptoms===
 
===Signs / Symptoms===
*[[Hashimoto thyroiditis]]: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
*[[Hashimoto thyroiditis]]: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
*Low blood pressure
*Low blood pressure
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*[[Hypogonadism]]
*[[Hypogonadism]]
*Diabetes mellitus
*Diabetes mellitus


=== APS-2 Entities / Miasms ===
=== APS-2 Entities / Miasms ===
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|
|
|}
|}
Note


It seems that APS could be a [[Cluster of disease|COD]].
 
=== Note ===
It seems that APS is a [[Cluster Of Entities|COE]].

Latest revision as of 09:22, 2 May 2023

Types

  • There are two distinct types APS-1 and APS-2
  • APS also named PAS

APS-1

Clinic

  • APS-1 causes the dysfunction of multiple endocrine glands due to autoimmunity.
  • It is an inherited in autosomal recessive fashion


Signs and symptoms

  • Chronic mucocutaneous candidiasis
  • Hypoparathyroidism
  • Addison's disease
  • Ectodermal dystrophy (Skin, Dental enamel, and Nails)


APS-1 may also cause:


APS-1 Entity / Miasm

HSV EBV CMV HCV MMP
Hepatitis +++ +++ +++ +++ +++
Infertitiy +++ +++
Vitiligo +++ +++
Atrophic Gastritis +++ +++
Cataract +
Cerebellar ataxia +++ +++ +++
Autoimmune adrenalitis ++ + +++
Alopecia +


APS-2

Clinic

  • It is the most common form
  • It is heterogeneous and has not been linked to one gene.
  • It affects women to a greater degree than men.


Signs / Symptoms

  • Hashimoto thyroiditis: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
  • Low blood pressure
  • Hypoparathyroidism
  • Myalgia
  • Graves' disease
  • Anemia
  • Hypogonadism
  • Diabetes mellitus


APS-2 Entities / Miasms

MTB MMP EBV HCV
Infertility +++ +++
Hashimoto thyroiditis +++ +++ +++ +++
Anemia +++ +++ +++
Diabetes mellitus, juvenile +++


Note

It seems that APS is a COE.

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