Autoimmune Polyendocrine Syndrome: Difference between revisions
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There are two distinct types APS-1 and APS-2 | === Types === | ||
* There are two distinct types APS-1 and APS-2 | |||
* APS also named PAS | |||
== APS-1 == | == APS-1 == | ||
=== Clinic === | === Clinic === | ||
* APS- | * APS-1causes the dysfunction of multiple endocrine glands due to autoimmunity. | ||
* It is an inherited in autosomal recessive fashion | * It is an inherited in autosomal recessive fashion | ||
| Line 11: | Line 13: | ||
=== Signs and symptoms === | === Signs and symptoms === | ||
* Chronic mucocutaneous candidiasis | * Chronic mucocutaneous candidiasis | ||
* Hypoparathyroidism | * Hypoparathyroidism | ||
* Addison's disease | * [[Addison's disease]] | ||
* Ectodermal dystrophy (skin, dental enamel, and nails) | * Ectodermal dystrophy (skin, dental enamel, and nails) | ||
APS-1 may also cause: | APS-1 may also cause: | ||
* Autoimmune hepatitis | * Autoimmune hepatitis | ||
* Hypogonadism | * [[Hypogonadism]] | ||
* Vitiligo | * [[Vitiligo]] | ||
* Alopecia | * [[Alopecia]] | ||
* Malabsorption | * Malabsorption | ||
* Pernicious anemia | * [[Pernicious anemia]] | ||
* Cataract | * [[Cataract]] | ||
* Cerebellar ataxia | * Cerebellar ataxia | ||
Revision as of 22:27, 5 April 2023
Types
- There are two distinct types APS-1 and APS-2
- APS also named PAS
APS-1
Clinic
- APS-1causes the dysfunction of multiple endocrine glands due to autoimmunity.
- It is an inherited in autosomal recessive fashion
Signs and symptoms
- Chronic mucocutaneous candidiasis
- Hypoparathyroidism
- Addison's disease
- Ectodermal dystrophy (skin, dental enamel, and nails)
APS-1 may also cause:
- Autoimmune hepatitis
- Hypogonadism
- Vitiligo
- Alopecia
- Malabsorption
- Pernicious anemia
- Cataract
- Cerebellar ataxia
APS-2
Clinic
- APS-2 a form of autoimmune polyendocrine syndrome also known as PAS II
- It is the most common form of the polyglandular failure syndromes.
- PAS II is defined as the association between autoimmune Addison's disease and either autoimmune thyroid disease, type 1 diabetes, or both.
- It is heterogeneous and has not been linked to one gene.
- APS-II affects women to a greater degree than men.
Signs and symptoms
- Hashimoto thyroiditis: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
- Low blood pressure
- Hypoparathyroidism
- Myalgia
- Graves' disease
- Anaemia
- Hypogonadism
- Diabetes mellitus
Entities / Miasms
| EBV | MTB | MMP | B19 | CXB | HCV | HSV | RBL | |
|---|---|---|---|---|---|---|---|---|
| Hashimoto thyroiditis | ++ | +++ | + | + | +++ | + | + | |
| Adrenal insufficiency | ++ | |||||||
| Diabetes Insulin dependent | +++ | +++ | +++ | +++ | ||||
| Female, Infertility / Oophoritis | +++ | +++ | ||||||
| Anemia | +++ | +++ | +++ | +++ | +++ | |||