Autism entities

Clinic

• Autism is a Neuro-Developmental disorder belonging to ASD
• Its symptoms first appears during infancy or childhood, and generally follows a steady course without remission.
• It is distinguished not by a single symptom but by a characteristic triad

1. Impairments in social interaction
2. Impairments in communication
3. Restricted interests & repetitive behavior.

Autism Characteristics

• Sensory integration
• Joint attention
• Stereotypes
• Immaturity in social relationships
• Speech problems

Sensory integration

• Disorder in neurobiological process of information processing including integration and interpretation of sensory information.
• Sensory integration clearly focuses on three functions

1. Tactile:
2. Vestibular: Ataxia
3. Proprioception: Sensory Ataxia

Joint attention

The two main prerequisite skills for joint attention are:

1. Following eye gaze
2. Identifying intention

The ability to engage in gaze is critical to establishing reference. Also, the ability to specify intention is necessary to learn the language and pay attention to others. So language development including understanding, producing and learning vocabulary is almost impossible without joint attention Therefore, the main rubrics of joint attention disorder are:

• Cognition impaired
• Aphasia
• Concentration, impaired

Stereotypes

• Restricted, repetitive behaviors (RRBs) includes stereotypic movements or routine interests and rituals. Its pathology is structural or functional defects of cortical-basal ganglia circuits.
• It is different from myoclonus, tic and jerking.
• It appears when the cognitive inhibition is decreased, therefore reflexes would appear
• I think its miasmatic similar is seizure.

Immaturity in social relationships

• Less eye contact and turn-taking
• Disability in Face expression/ Pointing at things
• Difficulty in Making / Maintaining friendships
• Unusual gestures
• Diminished responsiveness, and vocal patterns that are not synchronized with the caregiver.
• Reverse pronouns
• Joint attention

Speech problems

• Autism causes disorders in the field of Language / Speech, but not in Phonologic disorders
• Although some autistics have problems in Understanding / Producing language and considered as MR, but Aspergers do not have speech problems.
• They are attracted to non-verbal stimuli, which results in a decreasing social activities.
• Echolalia is common in autism. It is a type of apraxia and both are considered tics.
• Autistics do not have a problem in producing sounds and articulating them, but they have unusual vocal tics or repetitions (I think it is similar to Tourette's)
• Their main problem is using language for social purposes
• So the question is: Is Aphasia a good miasmatic rubric for Autism?

Researches

Autism related Encephalitis

The possibility of an autoimmune encephalitis in ASD is biologically reasonable because ASDs have specific comorbidities related to immune system involvement such as allergies and autoimmune diseases.

In an animal study, the neurotoxic effects of the injection of immunological mediators in the cerebral ventricles of mice were investigated, and the social communication disorder of the mice was clearly proven after the injection.

Three kind of Autoimmune encephalitis is considered:

1. Potassium channel complex antibody associated Encephalitis (Miasm: CJD)
2. NMDA receptor Encephalitis (Miasm: JE)
3. Hashimoto’s Encephalitis

NMDR encephalitis & Autism

69% of autistics have some degree of encephalitis, esp NMDR encephalitis.

This association is evidenced by the sharing of the following symptoms:

• Seizures
• Hypertention
• Stereotypical movements
• Aphasia
• Cognitive problems
• Psychosis

Cerebellocortical loops

Cerebellar involvement in cognition, as well as in sensorimotor control, is increasingly recognized and is thought to depend on connections with the cerebral cortex. Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebellar connections are contralateral to each other and include the

1. Cerebello-thalamo-cortical (CTC)
2. Cortico-ponto-cerebellar (CPC) pathways

Overall, all these findings support that the cerebellum has indeed an important role in cognition which is done by Cerebellocortical loops.

New understanding of the cerebellar connectivity in humans in vivo would provide essential information for determining the pathophysiological mechanisms involved in a number of clinical conditions. Indeed, an increasing number of investigations suggest that the abnormal functioning of these loops may subtend major neurological conditions including dystonia, ataxia, hemiplegia, stroke and autism.

There are two types of circuits that originate from cerebellum and ends in cortex. First one ends in PFC and the other to the sensory-motor cortex

In ASD, these two circuits become Overactive / Underactive which means cerebellum is probably involved in ASD.

It is not bad to check these two circuits separately without dependence on each other. On closer inspection, I realized that these are not two circuits.

The cerebellum circuit is connected to the cortex sensor, which is responsible for reducing the perception of sensory stimuli caused by our own body, for example, you cannot tickle yourself, or the decrease in the activity of this circuit in schizophrenics causes hallucinations. How about autism? Myself: increasing the activity of this circuit causes a decrease in the perception of sensory stimuli caused by the person's own body.

Cerebulocortical pathways, which leaves an important question in front of us. Is the miasmatic equivalent of cerebellar ataxia?

NO, Cerebellum has two different function. Its first known function is Motor/ Balance and Cognition / Language. In cerebellar ataxia Motor function is disturbed but we have another disease of cerebellum (CCAS) which is specifically involved in cognitive problems.

With this reasoning, with the mentioned symptoms, only the JE miasm comes with high power.

Perhaps the best example can be found in Cerebellar Cognitive Affective Syndrome. CCAS is caused by damage to the posterior lobe of the cerebellum, it has four characteristics that overlap with autism, and recently its Developmental type has also been discovered, which strongly overlaps with autism. cerebellar vermis and para-vermian area is the main center of its pathology

Autism Black Box

Disease	Entities	Miasms	Remedies
Asperger PDD-NOS (Atypical autism) CDD HF Autism	Aphasia Seizure esp Kozhevnikov Ataxia / Incoordination Psychosis	JE: If psychosis is present TBE: VZV

Autism Black Box

ASD	Aphasia	Seizure esp Kozhevnikov	Ataxia / Incoordination	Cerebellar Ataxia	Psychosis
Asperger	---	+++	+++		+++
PDD-NOS (Atypical autism)
CDD
HF Autism

Radar rubrics

Autism, children in

Mind- Ritualistic behavior

MIND - TALKING - slow learning to talk: agar. AGRA.  aloe bar-c. Bell. borx. calc-p. calc. caust. mag-c. med. NAT-M. nux-m. op. ph-ac. phos. plb. sanic. sil. sulph. thuj. tub.

GENERALS - DEVELOPMENT - arrested: Agar. aloe ant-c. bac. Bar-c. bar-m. bar-p. bar-s. borx. bufo CALC-P. Calc. Carc. caust. cupr. des-ac. hypoth. kreos. lac-d. lyc. med. nat-m. nep. ol-an. ph-ac. Phos. pin-s. rad-br. Sil. sulfa. syph. thym-gl. thyr. toxo-g. tub. vip.

MIND - GESTURES, makes - automatic: anac. anh. bell. calc. cann-i. falco-pe. hell. hydrog. hyos. lyc. mag-c. Nux-m. phos. polys. sil. Stram. syph. tab. tub. Verat. zinc.

GENERALS - DEVELOPMENT - slow : bar-c. bufo calc-p. cupr. mag-m. sil. sulph. toxo-g.

Indifference, relation to

Indifference, others, toward

Indifference, company, society to

Indifference, family to

Awkwardness, drop things

Childish behavior

Walking, toes

Incoordination

Flabby feeling

Dogmatic

Remedies

1. PHOS
2. Agar, Caust, Calc
3. Sil, Op, Nat-m, Cupr
4. Bufo, Thuj, Ant-c

Re

1. Carc: Very effective in autistic children, who are talented but are obsessive, compulsive, stubborn, and also have sleep-related issues. These children may also have addictive disorders.
2. Agar: They are mentally and physically awkward and show symptoms like indifference, muttering, talking, shouting, or singing but not answering to direct calls or questions. They suffer from involuntary jerking when they are awake.
3. Cupr: This works wonders when the child is being very obsessive, angry, and is inflexible, tense, and is very aggressive towards their parents. Some of these children may even exhibit malicious behaviors and are usually averse to touch or being approached.
4. Androctonus - A child or a patient who tends to swing wildly from a stable good mood to a destructive mode can be calmed down or evened out by homeopathic medicine Androctonus. These children also exhibit behaviors of suspiciousness and quickness to act on their compulsion.
5. Hell: They are slow and under active and seems to be depressed most of the time. Some of these children may also have muscular weakness.