Autoimmune Polyendocrine Syndrome

Types

• There are two distinct types APS-1 and APS-2
• APS also named PAS

APS-1

Clinic

• APS-1causes the dysfunction of multiple endocrine glands due to autoimmunity.
• It is an inherited in autosomal recessive fashion

Signs and symptoms

• Chronic mucocutaneous candidiasis
• Hypoparathyroidism
• Addison's disease
• Ectodermal dystrophy (skin, dental enamel, and nails)

APS-1 may also cause:

• Autoimmune hepatitis
• Hypogonadism
• Vitiligo
• Alopecia
• Malabsorption
• Pernicious anemia
• Cataract
• Cerebellar ataxia

APS-1 Entity / Miasm

	HCV	HSV	MMP	EBV	CMV
Hepatitis	+++	+++	+++	+++	+++
Infertitiy	+++		+++
Vitiligo		+++			+++
Atrophic Gastritis	+++			+++
Cataract
Cerebellar ataxia		+++	+++	+++
Autoimmune adrenalitis		++		+	+++

APS-2

Clinic

• It is the most common form
• It is heterogeneous and has not been linked to one gene.
• It affects women to a greater degree than men.

Signs and symptoms

• Hashimoto thyroiditis: Nausea, Frequent urination, Palpitations, Weight loss, Anorexia
• Low blood pressure
• Hypoparathyroidism
• Myalgia
• Graves' disease
• Anemia
• Hypogonadism
• Diabetes mellitus

APS-2 Entities / Miasms

	MTB	MMP	EBV	HCV
Infertility	+++	+++
Hashimoto thyroiditis	+++	+++	+++	+++
Anemia	+++		+++	+++
Diabetes mellitus, juvenile		+++

Note

It seems that APS could be a COD.