Ovarian failure

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Types

Premature ovarian failure

  • Also called Primary ovarian insufficiency, premature menopause
  • POF is a primary ovarian defect characterized by primary amenorrhea or premature depletion of ovarian follicles before the age of 40 years (secondary amenorrhea).
  • It is a heterogeneous disorder affecting approximately 1% of women <40 years
  • The most severe forms present with absent pubertal development and primary amenorrhea, whereas forms with post-pubertal onset are characterized by secondary amenorrhea associated with premature follicular depletion.
  • As in the case of physiological menopause, POF presents by typical manifestations of climacterium: Infertility associated with palpitations, heat intolerance, flushes, anxiety, depression, fatigue.
  • Beyond infertility, hormone defects may cause severe neurological, metabolic or cardiovascular consequences and lead to the early onset of osteoporosis.
  • Heterogeneity of POF is also reflected by the variety of possible causes, including autoimmunity, toxics, drugs, as well as genetic defects.


Triad of diagnosis:
  • Amenorrhea,
  • Hypergonadotropism: High levels of gonadotropins (LH and FSH) (hypergonadotropic amenorrhea)
  • Hypoestrogenism: Low levels of gonadal hormones (estrogens and inhibins)


Causes
  • Idiopathic in 90%
  • Auto immune:
  • Other causes include chemotherapy, being a carrier of the fragile X syndrome gene, radiotherapy, Cigarette smoking, higher body mass index, racial and ethnic factors, illnesses, and the removal of the uterus.
  • Genetic disorders such as Turner syndrome and Fragile X syndrome, metabolic defects, and enzyme defects.


Secondary ovarian failure

  • In secondary OF, ovaries are normal but there is a problem getting hormone signals to them from the brain.
  • This is usually caused by diseases of the pituitary gland or hypothalamus. (Hypopituitarism)
  • It may also caused by certain medicines, too much exercise, or certain eating disorders.
  • Some women with secondary ovarian failure sometimes have menstrual periods and may be able to have children.
  • Hypogonadotropic hypogonadism


Miasms


Remedies

Sep 200

  • Top remedy of anovulation.
  • Late and scanty menses.
  • Bearing down sensations in pelvic region.
  • Ovaries remain enlarged with fluid-filled cysts in them.
  • Infertility due to PCOS.
  • Face hirsutism, esp on upper lips
  • Sensitivity to cold air
  • Mental irritability
  • Indifferent behavior towards loved ones.


Puls 30

  • PCOS Anovulation esp in females who suffer from suppressed menses for a long duration.
  • Menses are very scanty and extremely painful
  • Esp in young girls at puberty who suffer from PCOS with irregular menses.
  • Total absence of thirst and a desire for cool open air.
  • Open air overall seems to provide relief to the patient.
  • Mild, sensitive nature with weeping tendencies.
  • She weeps at the slightest instance and feels somewhat better when given consolation


Calc 200

  • PCOS + Anovulation
  • Profuse menses that are prolonged more than the usual duration
  • Weight gain and Obesity
  • Excessive sweating on the head
  • Extreme sensitivity to cold air
  • Peculiar craving in eating habits like a desire for boiled eggs and in a few cases, strange things like chalk and lime.


Nat-m 200

  • Anovulation who have irregular and suppressed menstrual cycles
  • Difficulty in conception due to PCOS
  • Excessively hot sensation, Aversion to heat of sun
  • Craving for extra salt in the diet
  • Reserved nature of patient, weeping spells especially when alone
  • Worsening of symptoms when sympathy is offered.


Thuj 200

  • Retarded menstrual flow with multiple cysts in ovaries
  • Abnormal growth / cysts or accumulation anywhere in the body
  • Most women requiring Thuj have cystic growths more pronounced in the left-side ovary.
  • Hirsutismdue to hormonal imbalance.


Kali-c 30

  • Anovulation when the menses are suppressed altogether for several months.
  • Backs and legs give out.
  • Violent backache , relieved by sitting and pressure.


Senec 30

  • Menses are suppressed but the woman feels that menses are about to come.
  • Symptoms related to menses are present like heaviness or pain in pelvis region and nausea, but the menstrual flow is absent.


Apis 3x

  • Anovulation due to cyst.
  • Menses suppressed with cerebral and head symptoms.
  • There is bearing down sensation as if menses were to appear.


Lach 200

  • Anovulation, Menses too short, too feeble.  
  • Painful Cyst
  • Esp in Left ovary
  • Pain agg in the morning.
  • Pains are relieved by menses flow.


Thyr 30

  • Thyrodinum is also effective remedy for treating anovulation due to thyroid dysfunction.
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