Vitiligo: Difference between revisions

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* Specific causes are unknown but studies suggest a link to immune system changes.
* Specific causes are unknown but studies suggest a link to immune system changes.
* Vitiligo results from the destruction of epidermal melanocytes by autoreactive cytotoxic T cells.  
* Vitiligo results from the destruction of epidermal melanocytes by autoreactive cytotoxic T cells.  
* It seems that vitiligo is a part of Autoimmune disease named [[Autoimmune Polyendocrine Syndrome|APS]]
* Vitiligo usually associated with diseases like [[Hypothyroidism|Thyroid abnormality]], [[Pernicious anemia]], [[SLE, Systemic lupus erythematosus|SLE]], [[diabetes mellitus]],[[IBD, Inflammatory bowel disease|IBD]], [[Rheumatoid Arthritis|RA]], etc.




=== Signs / Symptoms ===
=== Signs / Symptoms ===


* The only sign of vitiligo is the presence of pale patchy areas of Depigmented skin which tend to occur on the extremities.
* The only sign of vitiligo is the presence of pale patchy areas of depigmented skin
* Sometimes itching before a new patch occurs.
* Rarely itching in the absence of sunburn.
*Patches are initially small, but often grow and change shape.  
*Patches are initially small, but often grow and change shape.  
*They are most prominent on the face, hands, wrists, around body orifices, such as the mouth, eyes, nostrils, genitalia and umbilicus.  
*They are most prominent on the face, hands, wrists, around body orifices, such as the mouth, eyes, nostrils, genitalia and umbilicus.  
*Some lesions have increased skin pigment around the edges.
*Some lesions have increased skin pigment around the edges.
* They may experience [[Depression remedies|depression]] and similar mood disorders.
* They may experience [[Depression remedies|depression]] and similar mood disorders.
* Koebner phenomenon: Damage to the normal skin frequently results in an area of depigmentation.
* Inflammatory Vitiligo has an erythematous raised border similar to the one sometimes seen in pityriasis versicolour.




==== Related disease ====


=== Related disease ===
* [[Hashimoto thyroiditis|Hashimoto's thyroiditis]]
* [[Hashimoto thyroiditis|Hashimoto's thyroiditis]]
*[[Scleroderma]]
*[[Scleroderma]]
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* [[Autoimmune Polyendocrine Syndrome]]
* [[Autoimmune Polyendocrine Syndrome]]


=== Note ===
=== Causes ===


* It seems that vitiligo is a part of Autoimmune disease named [[Autoimmune Polyendocrine Syndrome|APS]]
* 6.25-38% of patients have family history for vitiligo  
* Vitiligo is considered as an autoimmune disease due to:
** The presence of melanocytes auto-antibodies.
** Associated with other autoimmune disorders.
** Auto-antibodies in first degree relatives of patients
** Associated with HLA – DR4, HLA-DR1.
** Melanocytes Destruction
 
=== Rubrics ===
 
* Face- Discoloration, White Spot: Ars, Merc, Nat-c
* Genitalia- Spots- Scrotum, White: Merc, Thuj
* Extremities, Discoloration, Upper Limbs, White, in Spot: Apis
* Extremities, Discoloration, Thigh, White, in Spot: Calc
* Extremities, Discoloration, Thigh, White Spot: Calc.
* Extremities, Discloration, Ankle, White, in Spot: Calc.
* Extremities, Discloration, Foot, White In Spot: Apis
* Skin, Discoloration, White, Spot: ''alum'', am-c, ars, ''aur, berb, calc'', carb-an, coca,  ''merc, nat-c'', nit-ac, ''phos, sep,'' sil, ''sulph''.
 
== [[Homeopathic remedies|Remedies]] ==
 
=== [[Nat-m, Natrium muriaticum|Nat-m]] ===
 
* Greasy/ Oily esp on hairy parts.
* Dry eruptions esp on the margins of the hairy scalp and bends of points
* Skin-raw, red, inflamed,
 
=== [[Nit-ac, Nitricum Acidum|Nit-ac]] ===
 
* Zig-zag, irregular edges, base look like raw flesh.
* Exuberant granulations,
* Forehead Papules: Large jagged, Bleeds on washing
* Sensitive splinter like pains
* Agg: Evening, night, cold climate also in hot weather.
 
=== [[Ars-s-f, Arsenicum Sulphuratum Flavum|Ars-s-f]] ===
 
* Leucoderma and squamous syphilitic diseases.
* Sciatica and pain around the knee.
* Associated with sense of needle pricks from within outwards in the chest and esp right side also on forehead
 
=== [[Ars, Arsenicum Album|Ars]] ===
 
* Skin oversensitive, suppressed eruptions.
* Brownish white spots in skin.
* White patches; dry, rough skin.
 
=== [[Sep, Sepia|Sep]] ===
 
* Delicate skin
 
 
=== [[Sil, Silicea|Sil]] ===
 
* Skin is delicate, pale, and waxy; a tendency to excessive perspiration.
 
=== [[Sul , Sulphur|Sul]] ===
 
=== [[Thuj , Thuja Occidentalis|Thuj]] ===
 
* Unhealthy skin; brown or brownish white spots here and there
 
* AMMI VISNAGA – Relieves issues of Vitiligo and reduces associated anxiety. Associated with treatment of spasmodic bodily movements and in the treatment of angina pectoris.
* PSOROLIA COR – It helps in the treatment of Leukoderma, Leprosy and skin diseases. It is also helpful for treating the scorpion sting and snake bites as it has antibacterial and antioxidant properties.

Revision as of 06:28, 8 July 2023

Clinic

  • Vitiligo is a disorder that causes the skin to lose its color.
  • Specific causes are unknown but studies suggest a link to immune system changes.
  • Vitiligo results from the destruction of epidermal melanocytes by autoreactive cytotoxic T cells.
  • It seems that vitiligo is a part of Autoimmune disease named APS
  • Vitiligo usually associated with diseases like Thyroid abnormality, Pernicious anemia, SLE, diabetes mellitus,IBD, RA, etc.


Signs / Symptoms

  • The only sign of vitiligo is the presence of pale patchy areas of depigmented skin
  • Rarely itching in the absence of sunburn.
  • Patches are initially small, but often grow and change shape.
  • They are most prominent on the face, hands, wrists, around body orifices, such as the mouth, eyes, nostrils, genitalia and umbilicus.
  • Some lesions have increased skin pigment around the edges.
  • They may experience depression and similar mood disorders.
  • Koebner phenomenon: Damage to the normal skin frequently results in an area of depigmentation.
  • Inflammatory Vitiligo has an erythematous raised border similar to the one sometimes seen in pityriasis versicolour.


Related disease

Causes

  • 6.25-38% of patients have family history for vitiligo
  • Vitiligo is considered as an autoimmune disease due to:
    • The presence of melanocytes auto-antibodies.
    • Associated with other autoimmune disorders.
    • Auto-antibodies in first degree relatives of patients
    • Associated with HLA – DR4, HLA-DR1.
    • Melanocytes Destruction

Rubrics

  • Face- Discoloration, White Spot: Ars, Merc, Nat-c
  • Genitalia- Spots- Scrotum, White: Merc, Thuj
  • Extremities, Discoloration, Upper Limbs, White, in Spot: Apis
  • Extremities, Discoloration, Thigh, White, in Spot: Calc
  • Extremities, Discoloration, Thigh, White Spot: Calc.
  • Extremities, Discloration, Ankle, White, in Spot: Calc.
  • Extremities, Discloration, Foot, White In Spot: Apis
  • Skin, Discoloration, White, Spot: alum, am-c, ars, aur, berb, calc, carb-an, coca,  merc, nat-c, nit-ac, phos, sep, sil, sulph.

Remedies

Nat-m

  • Greasy/ Oily esp on hairy parts.
  • Dry eruptions esp on the margins of the hairy scalp and bends of points
  • Skin-raw, red, inflamed,

Nit-ac

  • Zig-zag, irregular edges, base look like raw flesh.
  • Exuberant granulations,
  • Forehead Papules: Large jagged, Bleeds on washing
  • Sensitive splinter like pains
  • Agg: Evening, night, cold climate also in hot weather.

Ars-s-f

  • Leucoderma and squamous syphilitic diseases.
  • Sciatica and pain around the knee.
  • Associated with sense of needle pricks from within outwards in the chest and esp right side also on forehead

Ars

  • Skin oversensitive, suppressed eruptions.
  • Brownish white spots in skin.
  • White patches; dry, rough skin.

Sep

  • Delicate skin


Sil

  • Skin is delicate, pale, and waxy; a tendency to excessive perspiration.

Sul

Thuj

  • Unhealthy skin; brown or brownish white spots here and there
  • AMMI VISNAGA – Relieves issues of Vitiligo and reduces associated anxiety. Associated with treatment of spasmodic bodily movements and in the treatment of angina pectoris.
  • PSOROLIA COR – It helps in the treatment of Leukoderma, Leprosy and skin diseases. It is also helpful for treating the scorpion sting and snake bites as it has antibacterial and antioxidant properties.
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