Fatigue

Clinic

• Fatigue is a SSP. It is state of Tiredness/ Exhaustion.
• In general usage, fatigue often follows prolonged physical or mental activity.
• Here in this article, I use Fatigue, when Exhaustion occurs independently of physical or mental exertion, therefore it does not resolve after rest or sleep.

• Fatigue as a Sign / Symptom should not be confused with ICF as an entity or CFS as a disease.

Related disease

Dynamic causes

• Autoimmune diseases, such as celiac disease, SLE, MS, Myasthenia gravis, Sjögren's syndrome, and spondyloarthropathy
• Anxiety disorders such as Generalized anxiety disorder
• Blood disorders such as Anemia and hemochromatosis
• Chronic fatigue syndrome
• Substance use disorders including alcohol use disorder
• Depression and other mental disorders that feature depressed mood
• Developmental disorders such as autism spectrum disorder
• Endocrine diseases or metabolic disorders: Diabetes mellitus and Addison’s disease
• Fibromyalgia
• Gulf War syndrome
• Idiopathic chronic fatigue (ICF)
• Infectious diseases such as Infectious mononucleosis, tuberculosis, Covid-19, HIV
• Irritable bowel syndrome
• Lyme disease
• Neurological disorders such as Narcolepsy, Parkinson's disease, Postural Orthostatic Tachycardia Syndrome

Static causes

• Brain injury
• Inborn errors of metabolism such as fructose malabsorption
• Stroke
• Sleep deprivation or sleep disorders, e.g. sleep apnea
• Thyroid disease such as hypothyroidism
• Physical trauma and other pain-causing conditions, such as arthritis
• Post-concussion syndrome
• Liver failure or liver diseases e.g. Hepatitis
• Kidney diseases e.g. acute renal failure, chronic renal failure
• Heart failure
• Eating disorders, which can produce fatigue due to inadequate nutrition
• Cancer fatigue, Leukemia or lymphoma