Bipolar disorder: Difference between revisions

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(Created page with "=== Clinic === * Previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood * If the elevated mood is severe or associated with psychosis, it is called mania; if it is less severe, it is called hypomania. * During mania, an individual behaves or feels abnormally energetic, happy or irritable, and they often make impulsive decisions with little regard for the consequences. There is usually a...")
 
 
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* Previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood  
* Previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood  
* If the elevated mood is severe or associated with psychosis, it is called mania; if it is less severe, it is called hypomania.  
* If the elevated mood is severe or associated with [[psychosis]], it is called mania; if it is less severe, it is called hypomania.  
* During mania, an individual behaves or feels abnormally energetic, happy or irritable, and they often make impulsive decisions with little regard for the consequences. There is usually also a reduced need for sleep during manic phases.  
* During mania, an individual behaves or feels abnormally energetic, happy or irritable, and they often make impulsive decisions with little regard for the consequences. There is usually also a reduced need for sleep during manic phases.  
* During periods of depression, the individual may experience crying and have a negative outlook on life and poor eye contact with others.
* Late adolescence and early adulthood are peak years for the onset of bipolar disorder
* High risk of suicide 
* Other mental health issues, such as anxiety disorders and substance use disorders, are commonly associated with bipolar disorder.
* Bipolar disorder occurs in approximately 1% of the global population
* Bipolar disorder occurs in approximately 1% of the global population
* Exact mechanism underlying the disorder remains unclear
* Exact mechanism underlying the disorder remains unclear


=== Signs / Symptoms ===
=== Signs / Symptoms ===


* Late adolescence and early adulthood are peak years for the onset of bipolar disorder. The condition is characterized by intermittent episodes of mania and/or depression, with an absence of symptoms in between.
* [[Depression]]: Crying, Negative outlook on life, Poor eye contact, Slowed movements
* Constant fidgeting during mania
* [[Mania remedies|Mania]]:
* Slowed movements during depression
** An increase in energy of psychomotor activity / Decreased need for sleep / Constant fidgeting
* Euphoria or dysphoria and irritability.
** High risk of suicide
* Psychotic symptoms such as delusions or hallucinations may occur in both manic and depressive episodes
** Euphoria or dysphoria, Irritability
** Increased self-esteem or grandiosity
** Racing thoughts
** Pressured speech that is difficult to interrupt
** Disinhibited social behavior
** Increased goal-oriented activities
**Impaired judgement, Impulsive or high-risk behaviors such as hypersexuality, Excessive spending.
* [[Psychosis]]: [[Delusion|Delusions]] (Grandiose), [[Hallucination|Hallucinations]]


 
=== Related states ===
=== Manic episodes ===
{| class="wikitable"
 
|+
* Elevated or irritable mood which can range from euphoria to delirium
!Hypomania
* Core symptom of mania is an increase in energy of psychomotor activity.
!Mixed affective episodes
* Increased self-esteem or grandiosity, racing thoughts, pressured speech that is difficult to interrupt, decreased need for sleep,
!Comorbid conditions
* Disinhibited social behavior
|-
* Increased goal-oriented activities
|
* Impaired judgement which can lead to exhibition of behaviors characterized as impulsive or high-risk, such as hypersexuality or excessive spending. To fit the definition of a manic episode, these behaviors must impair the individual's ability to socialize or work. If untreated, a manic episode usually lasts three to six months.
*Hypomania is the milder form of mania, defined as at least four days of the same criteria as mania, but which does not cause a significant decrease in the individual's ability to socialize or work,  
* In severe manic episodes, a person can experience psychotic symptoms, where thought content is affected along with mood. They may feel unstoppable, or as if they have a special relationship with God, a great mission to accomplish, or other grandiose or delusional ideas. This may lead to violent behavior and, sometimes, hospitalization in an inpatient psychiatric hospital. The severity of manic symptoms can be measured by rating scales such as the Young Mania Rating Scale, though questions remain about the reliability of these scales.
* It lacks psychotic features such as delusions or hallucinations, and does not require psychiatric hospitalization.
 
|
The onset of a manic or depressive episode is often foreshadowed by sleep disturbance. Manic individuals often have a history of substance use disorder developed over years as a form of "self-medication".
*In bipolar disorder, a mixed state is an episode during which symptoms of both mania and depression occur simultaneously.  
 
* Individuals experiencing a mixed state may have manic symptoms such as grandiose thoughts while simultaneously experiencing depressive symptoms such as excessive guilt or feeling suicidal.
=== Hypomanic episodes ===
* They are considered to have a higher risk for suicidal behavior as depressive emotions such as hopelessness are often paired with mood swings or difficulties with impulse control.
An 1858 lithograph captioned 'Melancholy passing into mania'
* Anxiety disorders occur more frequently as a comorbidity in mixed bipolar episodes than in non-mixed bipolar depression or mania.
Hypomania is the milder form of mania, defined as at least four days of the same criteria as mania, but which does not cause a significant decrease in the individual's ability to socialize or work, lacks psychotic features such as delusions or hallucinations, and does not require psychiatric hospitalization. Overall functioning may actually increase during episodes of hypomania and is thought to serve as a defense mechanism against depression by some. Hypomanic episodes rarely progress to full-blown manic episodes. Some people who experience hypomania show increased creativity, while others are irritable or demonstrate poor judgment.
* Substance (including alcohol) use also follows this trend, thereby appearing to depict bipolar symptoms as no more than a consequence of substance use.
 
|
Hypomania may feel good to some individuals who experience it, though most people who experience hypomania state that the stress of the experience is very painful. People with bipolar disorder who experience hypomania tend to forget the effects of their actions on those around them. Even when family and friends recognize mood swings, the individual will often deny that anything is wrong. If not accompanied by depressive episodes, hypomanic episodes are often not deemed problematic unless the mood changes are uncontrollable or volatile. Most commonly, symptoms continue for time periods from a few weeks to a few months.
*[[Anxiety]] (71%)
 
=== Depressive episodes ===
Main article: Major depressive disorder
'Melancholy' by William Bagg, after a photograph by Hugh Welch Diamond
Symptoms of the depressive phase of bipolar disorder include persistent feelings of sadness, irritability or anger, loss of interest in previously enjoyed activities, excessive or inappropriate guilt, hopelessness, sleeping too much or not enough, changes in appetite and/or weight, fatigue, problems concentrating, self-loathing or feelings of worthlessness, and thoughts of death or suicide. Although the DSM-5 criteria for diagnosing unipolar and bipolar episodes are the same, some clinical features are more common in the latter, including increased sleep, sudden onset and resolution of symptoms, significant weight gain or loss, and severe episodes after childbirth.
 
The earlier the age of onset, the more likely the first few episodes are to be depressive. For most people with bipolar types 1 and 2, the depressive episodes are much longer than the manic or hypomanic episodes. Since a diagnosis of bipolar disorder requires a manic or hypomanic episode, many affected individuals are initially misdiagnosed as having major depression and incorrectly treated with prescribed antidepressants.
 
=== Mixed affective episodes ===
Main article: Mixed affective state
 
In bipolar disorder, a mixed state is an episode during which symptoms of both mania and depression occur simultaneously. Individuals experiencing a mixed state may have manic symptoms such as grandiose thoughts while simultaneously experiencing depressive symptoms such as excessive guilt or feeling suicidal. They are considered to have a higher risk for suicidal behavior as depressive emotions such as hopelessness are often paired with mood swings or difficulties with impulse control. Anxiety disorders occur more frequently as a comorbidity in mixed bipolar episodes than in non-mixed bipolar depression or mania. Substance (including alcohol) use also follows this trend, thereby appearing to depict bipolar symptoms as no more than a consequence of substance use.
 
=== Comorbid conditions ===
 
* [[Anxiety]] (71% of people with bipolar disorder)
* [[Substance use disorder|Substance abuse]] (56%)
* [[Substance use disorder|Substance abuse]] (56%)
* Personality disorders (36%)  
* Personality disorders (36%)
* Attention deficit hyperactivity disorder (10–20%)
* [[ADHD|Attention deficit hyperactivity disorder]] (10–20%)
 
Certain medical conditions such as


* [[Metabolic syndrome]] (37%)
* [[Metabolic syndrome]] (37%)
* [[Migraine headache|Migraine headaches]] (35%),
* [[Migraine headache|Migraine headaches]] (35%)
* Obesity (21%)  
* Obesity (21%)
* [[Type 2 DM|Type 2 diabetes]] (14%)
* [[Type 2 DM|Type 2 diabetes]] (14%)
 
|}
 
=== [[Entities list|Entities]] / [[Viral miasms|Miasms]] ===
{| class="wikitable"
{| class="wikitable"
|+Entities / Miasms
!
!
!GSS
![[GSS, Gerstmann Straussler Scheinker syndrome|GSS]]
!STLE
![[STLE, St Louis Encephalitis|STLE]]
!TBE
![[TBE, Tick Borne Encephalitis|TBE]]
|-
|-
|Emotional lability  
|[[Pseudobulbar affect|Emotional lability]]
| +++
| +++
| +++
| +++
| +++
| +++
|-
|-
|Hallucinations / Delusions
|[[Hallucination|Hallucinations]] / [[Delusion|Delusions]]
|
|
| +++
| +++
| +++
| +++
|-
|-
|Depression
|[[Depression]]
| +++
| +++
| +++
| +++
|
|
|-
|-
|Psychosis
|[[Psychosis]]
| +++
| +++
|
|
|
|
|}
===Research===
*CMV and [[Bipolar disorder|Bipolar disease]]. <ref>Frye MA, Coombes BJ, McElroy SL, Jones-Brando L, Bond DJ, Veldic M, Romo-Nava F, Bobo WV, Singh B, Colby C, Skime MK, Biernacka JM, Yolken R. Association of Cytomegalovirus and Toxoplasma gondii Antibody Titers With Bipolar Disorder. JAMA Psychiatry. 2019 Dec 1;76(12):1285-1293. doi: 10.1001/jamapsychiatry.2019.2499. PMID: 31532468; PMCID: PMC6751798.</ref> <ref>Prossin AR, Yolken RH, Kamali M, Heitzeg MM, Kaplow JB, Coryell WH, McInnis MG. Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States. Neural Plast. 2015;2015:939780. doi: 10.1155/2015/939780. Epub 2015 May 13. PMID: 26075105; PMCID: PMC4444593.</ref>
== Remedies ==
{| class="wikitable"
|+
!Depression stage
!Manic stage
!Changing mood
|-
|
*[[Anac, Anacardium Orientale|Anac]]
* [[Sep, Sepia|Sep]]
* [[Naja, Naja tripudians|Naja]]
|
*Bell
* Stram
* Hyos
* Tarant
* Syph
|[[Ign, Ignatia Amara|Ign]]: [[Hysteria]] + Changing symptoms
[[Med, Medorrhinum|Med]]
carc: [[Hysteria]] + Changing symptoms
'''[[Puls, Pulsatilla pratensis|PULS]]: [[Hysteria]] + Changing symptoms'''
|}
{| class="wikitable"
|+
!
!
!
|-
| rowspan="3" |'''<big>Mood Swings</big>'''
|
=== [[Cocc, Cocculus Indicus|Cocc]] ===
|
* Mood swings esp Happiness and Anger/ Sadness . 
* Tears suddenly arise after laughter.
* Listening to music makes the moods worse.
* Mental symptoms alternating with physical symptoms
|-
|
=== [[Puls, Pulsatilla pratensis|Puls]] ===
|
* '''Sensitive nature'''
* Alternate between tears and laughter easily.
* Oversensitive and get offended quickly.
* They look for consolation and feel better when consoled.
* Being in the open also makes them feel better.
* A history of silent grief
|-
|
=== [[Ars, Arsenicum Album|Ars]] ===
|
* Anxious Personalities
* Sudden mood changes along with anxiety, mainly about health and the future
* Extreme restlessness, both on the mental and physical plane
* Fears like the fear of catching an infection or the fear of financial loss.
* Fastidiousness and the demand for cleanliness and order in everything.
|-
| rowspan="3" |'''<big>Depression stage</big>'''
|
=== [[Ign, Ignatia Amara|Ign]] ===
|
* Sudden mood changes from sadness to happiness, and from weeping to laughter.
* Uncontrollable emotions with a sudden alteration in mood.
* Esp depressed.
* Dwell on some disagreeable events in the past
* Sleeping problems.
* History of emotional shock or grief.
* She sit silently and weep or brood over the past.
|-
|
=== [[Sep, Sepia|Sep]] ===
|
* Menstruation-related mood swing
* Mood swings due to hormonal changes, mostly arising before menses or around [[menopause]].
* A lot of irritability, getting offended easily
* Indifferent behavior toward family members and friends.
* Low energy levels: Lack of interest in doing any sort of work.
* Depression stage of Bipolar Disorder: Constant weeping, indifferent behavior towards people and even family members who were once much respected and loved, and lack of interest in doing any mental or physical work.
|-
|
=== [[Ambr, Ambra grisea|Ambr]] ===
|Some kind of business loss + Continuous weeping for many days.
|-
| rowspan="2" |'''<big>Increased Energy Levels</big>'''
|
=== [[Lil-t, Lilium Tigrinum|Lil-t]] ===
|
* Extreme restlessness and difficulty in sitting still at one place.
* Great hurriedness without any ambition or aim.
* Heart or uterine disease associated with the mental symptoms.
|-
|
=== [[Cann-i, Cannabis Indica|Cann-i]] ===
|
* Bouts of uncontrollable laughter on listening to every little word spoken, which may not even be funny.
* Excessive talkativeness.
* Full of thoughts crowding the brain at one time, making the patient forgetful of words while talking.
|-
| rowspan="3" |'''<big>Violent / Aggressive Behavior</big>'''
|
=== [[Bell, Belladona|Bell]] ===
|
* Het even bites and strikes the person near him or her.
* The patient spits on people and the face turns red.
|-
|
=== [[Verat, Veratrum album|Verat]] ===
|
* Violent behavior of persons suffering from Bipolar Disorder is Veratrum Album
* Excessive Shrieking /Screaming
* Destructive behavior: Destroying, cutting and tearing apart everything, most likely clothes.
* Violent mania that start in a woman after childbirth
|-
|
=== [[Hyos, Hyoscyamus Niger|Hyos]] ===
|
* Desire to run away from home
* Picking at bedclothes
* Quarreling with others
* Shamelessness where the patient tends to remove his clothes and sings obscene songs.
|-
| rowspan="2" |'''<big>Depression + Suicidal Thoughts</big>'''
|
=== [[Aur, Aurum Metallicum|Aur]] ===
|
* Hopeless and worthless and has persistent suicidal thoughts.
|-
|
=== [[Nat-s, Natrum Sulphuricum|Nat-s]] ===
|
* She has to apply much self-control to stop herself from actually committing suicide.
* Gloominess.
* She feels sad even when listening to lively music
* Aversion to talk or be spoken to.
|}
|}

Latest revision as of 05:38, 12 January 2024

Clinic

  • Previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood
  • If the elevated mood is severe or associated with psychosis, it is called mania; if it is less severe, it is called hypomania.
  • During mania, an individual behaves or feels abnormally energetic, happy or irritable, and they often make impulsive decisions with little regard for the consequences. There is usually also a reduced need for sleep during manic phases.
  • Late adolescence and early adulthood are peak years for the onset of bipolar disorder
  • Bipolar disorder occurs in approximately 1% of the global population
  • Exact mechanism underlying the disorder remains unclear


Signs / Symptoms

  • Depression: Crying, Negative outlook on life, Poor eye contact, Slowed movements
  • Mania:
    • An increase in energy of psychomotor activity / Decreased need for sleep / Constant fidgeting
    • High risk of suicide
    • Euphoria or dysphoria, Irritability
    • Increased self-esteem or grandiosity
    • Racing thoughts
    • Pressured speech that is difficult to interrupt
    • Disinhibited social behavior
    • Increased goal-oriented activities
    • Impaired judgement, Impulsive or high-risk behaviors such as hypersexuality, Excessive spending.
  • Psychosis: Delusions (Grandiose), Hallucinations

Related states

Hypomania Mixed affective episodes Comorbid conditions
  • Hypomania is the milder form of mania, defined as at least four days of the same criteria as mania, but which does not cause a significant decrease in the individual's ability to socialize or work,
  • It lacks psychotic features such as delusions or hallucinations, and does not require psychiatric hospitalization.
  • In bipolar disorder, a mixed state is an episode during which symptoms of both mania and depression occur simultaneously.
  • Individuals experiencing a mixed state may have manic symptoms such as grandiose thoughts while simultaneously experiencing depressive symptoms such as excessive guilt or feeling suicidal.
  • They are considered to have a higher risk for suicidal behavior as depressive emotions such as hopelessness are often paired with mood swings or difficulties with impulse control.
  • Anxiety disorders occur more frequently as a comorbidity in mixed bipolar episodes than in non-mixed bipolar depression or mania.
  • Substance (including alcohol) use also follows this trend, thereby appearing to depict bipolar symptoms as no more than a consequence of substance use.

Entities / Miasms

GSS STLE TBE
Emotional lability +++ +++ +++
Hallucinations / Delusions +++ +++
Depression +++ +++
Psychosis +++

Research

Remedies

Depression stage Manic stage Changing mood
  • Bell
  • Stram
  • Hyos
  • Tarant
  • Syph
 Ign: Hysteria + Changing symptoms

Med

carc: Hysteria + Changing symptoms

PULS: Hysteria + Changing symptoms

Mood Swings

Cocc
  • Mood swings esp Happiness and Anger/ Sadness .
  • Tears suddenly arise after laughter.
  • Listening to music makes the moods worse.
  • Mental symptoms alternating with physical symptoms

Puls
  • Sensitive nature
  • Alternate between tears and laughter easily.
  • Oversensitive and get offended quickly.
  • They look for consolation and feel better when consoled.
  • Being in the open also makes them feel better.
  • A history of silent grief

Ars
  • Anxious Personalities
  • Sudden mood changes along with anxiety, mainly about health and the future
  • Extreme restlessness, both on the mental and physical plane
  • Fears like the fear of catching an infection or the fear of financial loss.
  • Fastidiousness and the demand for cleanliness and order in everything.
Depression stage

Ign
  • Sudden mood changes from sadness to happiness, and from weeping to laughter.
  • Uncontrollable emotions with a sudden alteration in mood.
  • Esp depressed.
  • Dwell on some disagreeable events in the past
  • Sleeping problems.
  • History of emotional shock or grief.
  • She sit silently and weep or brood over the past.

Sep
  • Menstruation-related mood swing
  • Mood swings due to hormonal changes, mostly arising before menses or around menopause.
  • A lot of irritability, getting offended easily
  • Indifferent behavior toward family members and friends.
  • Low energy levels: Lack of interest in doing any sort of work.
  • Depression stage of Bipolar Disorder: Constant weeping, indifferent behavior towards people and even family members who were once much respected and loved, and lack of interest in doing any mental or physical work.

Ambr

 Some kind of business loss + Continuous weeping for many days.
Increased Energy Levels

Lil-t
  • Extreme restlessness and difficulty in sitting still at one place.
  • Great hurriedness without any ambition or aim.
  • Heart or uterine disease associated with the mental symptoms.

Cann-i
  • Bouts of uncontrollable laughter on listening to every little word spoken, which may not even be funny.
  • Excessive talkativeness.
  • Full of thoughts crowding the brain at one time, making the patient forgetful of words while talking.
Violent / Aggressive Behavior

Bell
  • Het even bites and strikes the person near him or her.
  • The patient spits on people and the face turns red.

Verat
  • Violent behavior of persons suffering from Bipolar Disorder is Veratrum Album
  • Excessive Shrieking /Screaming
  • Destructive behavior: Destroying, cutting and tearing apart everything, most likely clothes.
  • Violent mania that start in a woman after childbirth

Hyos
  • Desire to run away from home
  • Picking at bedclothes
  • Quarreling with others
  • Shamelessness where the patient tends to remove his clothes and sings obscene songs.
Depression + Suicidal Thoughts

Aur
  • Hopeless and worthless and has persistent suicidal thoughts.

Nat-s
  • She has to apply much self-control to stop herself from actually committing suicide.
  • Gloominess.
  • She feels sad even when listening to lively music
  • Aversion to talk or be spoken to.
  1. ↑ Frye MA, Coombes BJ, McElroy SL, Jones-Brando L, Bond DJ, Veldic M, Romo-Nava F, Bobo WV, Singh B, Colby C, Skime MK, Biernacka JM, Yolken R. Association of Cytomegalovirus and Toxoplasma gondii Antibody Titers With Bipolar Disorder. JAMA Psychiatry. 2019 Dec 1;76(12):1285-1293. doi: 10.1001/jamapsychiatry.2019.2499. PMID: 31532468; PMCID: PMC6751798.
  2. ↑ Prossin AR, Yolken RH, Kamali M, Heitzeg MM, Kaplow JB, Coryell WH, McInnis MG. Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States. Neural Plast. 2015;2015:939780. doi: 10.1155/2015/939780. Epub 2015 May 13. PMID: 26075105; PMCID: PMC4444593.
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