EBV, Epstein Barr Virus

Clinic

• EBV is one of the nine known human herpesvirus types in the herpes family
• It is one of the most common viral miasms in human.
• It is best known as the cause of infectious mononucleosis.

Related disease

• Non-lymphoid malignancies such as
  • Gastric cancer
  • External throat: Nasopharyngeal carcinoma
  • Jaw tumor
  • Pericardial tumor
  • Breast; cancer
  • Pleural tumor
  • Liver cancer
• Conditions associated with HIV such as
  • Oral Hairy leukoplakia : White or red discoloration of tongue. Tongue; white lesion on the lateral.
  • CNS lymphomas
• Autoimmune disorders
  • MS

• Gianotti–Crosti syndrome
• Erythema multiforme
• Acute genital ulcers  

Infectious mononucleosis

• Fatigue, fever, inflamed throat, swollen lymph nodes in the neck, enlarged spleen, swollen liver, or rash.
• Chronic Fatigue Syndrome

• Severe hypersensitivity, Mosquito bite allergy reactions
• Mucocutaneous ulcers
• Hydroa vacciniforme

Entities	Sign / Symptoms	Related disease
Uveitis
Optic neuritis
Pharyngitis Tonsillitis	Sore throat Erythematous Swelling of tonsils xudation Tonsils meet at the midline Ulcers.
Interstitial nephritis	Hematuria; microscopic. Increased Sediment Urine Proteinuria	Acute Renal failure
Pericarditis Myocarditis	Palpitation
Pneumonia Interstitial pneumonitis:	Cough
Arthritis		SLE Rheumatoid arthritis Sjögren's syndrome
Hepatitis	Hepatomegaly Tenderness / fullness of Right upper quadrant of Abdomen Elevated right hemidiaphragm Yellow face Nausea. Vomiting. LFT rising	Fulminant Hepatitis Persistent Hepatitis Hepatic failure Cirrhosis
	Splenomegaly Discomfort Pain; left upper quadrant ext to left scapular region Abrupt Pain Petechiae esp on Palate`	Splenic subcapsular bleeding Splenic subcapsular hematoma Splenic rupture
	Eruptions Erythema multiforme - like, macular Scarlatiniform
Lymphadenitis	Lymphadenopathy Axillary, Submandibular, Symmetrical Cervical, Inguinal , Back Adenopathy	Infectious mononucleosis Lymphoproliferative diseases such as Burkitt lymphoma Hemophagocytic lymphohistiocytosis Hodgkin's lymphoma
	Urticaria Ampicillin-induced Rash
Encephalitis	Fever (18%), Headache (66%) Seizures (48%) EEG signs (57%) Abnormal MRI findings (71%): Basal ganglia and the striatal body, esp in the putamen and caudate nucleus	Acute childhood encephalitis Alice in Wonderland syndrome
Aseptic meningitis:	Retro-orbital Headache
	Transverse myelitis Brachial plexus neuropathy	Guillain-Barre syndrome
Bel’s palsy
Cerebellar ataxia		Acute cerebellar ataxia
		Dermatomyositis

• Periorbital edema

• Nose Catarrh.

• Mouth Offensive odor. Palatal enanthem at the junction of soft and hard palate. Lip ulcers. Cracked tongue.

• Constipation. Diarrhea.
• Hemorrhoids: Rectum Pain
• Acrid Leukorrhea
• Trembling of hands. Hemiplegia
• Ulcers
• Fever: afternoon, low grade, prolonged.