EBV, Epstein Barr Virus

Clinic

• EBV is one of the nine known human herpesvirus types in the herpes family
• It is one of the most common viral miasms in human.
• It is best known as the cause of infectious mononucleosis.

Related disease

• Non-lymphoid malignancies such as
  • Gastric cancer
  • External throat: Nasopharyngeal carcinoma
  • Jaw tumor
  • Pericardial tumor
  • Breast; cancer
  • Pleural tumor
  • Liver cancer
• Conditions associated with HIV such as
  • Oral Hairy leukoplakia : White or red discoloration of tongue. Tongue; white lesion on the lateral.
  • CNS lymphomas
• Autoimmune disorders
  • MS

• Gianotti–Crosti syndrome
• Erythema multiforme
• Acute genital ulcers  

Infectious mononucleosis

• Fatigue, fever, inflamed throat, swollen lymph nodes in the neck, enlarged spleen, swollen liver, or rash.
• Chronic Fatigue Syndrome

• Severe hypersensitivity, Mosquito bite allergy reactions
• Mucocutaneous ulcers
• Hydroa vacciniforme

Entities	Sign / Symptoms	Related disease
Uveitis
Optic neuritis		MS
Pharyngitis Tonsillitis	Sore throat Erythematous Swelling of tonsils xudation Tonsils meet at the midline Ulcers.
Interstitial nephritis	Microscopic Hematuria Increased Sediment Urine Proteinuria Periorbital edema	Acute Renal failure
Pericarditis Myocarditis	Palpitation
Pneumonia Interstitial pneumonitis:	Cough
Arthritis		SLE Rheumatoid arthritis Sjögren's syndrome
Hepatitis	Hepatomegaly Tenderness / fullness of Right upper quadrant of Abdomen Elevated right hemidiaphragm Yellow face Nausea. Vomiting. LFT rising	Fulminant Hepatitis Persistent Hepatitis Hepatic failure Cirrhosis
	Splenomegaly Pain/ Discomfort; left upper quadrant ext to left scapular region Abrupt Pain Petechiae esp on Palate`	Splenic subcapsular bleeding Splenic subcapsular hematoma Splenic rupture
	Eruptions Erythema multiforme - like, macular Scarlatiniform
Lymphadenitis	Lymphadenopathy Axillary, Submandibular, Symmetrical Cervical, Inguinal , Back Adenopathy	Infectious mononucleosis Lymphoproliferative diseases such as Burkitt lymphoma Hemophagocytic lymphohistiocytosis Hodgkin's lymphoma
	Urticaria Ampicillin-induced Rash	Severe hypersensitivity Mosquito bite allergy reactions
Encephalitis	Fever (18%) Headache (66%) Seizures (48%) EEG signs (57%) Abnormal MRI findings (71%): Basal ganglia and the striatal body, esp in the putamen and caudate nucleus	Acute childhood encephalitis Alice in Wonderland syndrome
Aseptic meningitis	Retro-orbital Headache
	Transverse myelitis Brachial plexus neuropathy	Guillain-Barre syndrome
Bel’s palsy
Cerebellar ataxia		Acute cerebellar ataxia
		Dermatomyositis
	Mouth Offensive odor Palatal enanthem at the junction of soft and hard palate Lip ulcers Cracked tongue

• Nose Catarrh

• Constipation. Diarrhea.
• Hemorrhoids: Rectum Pain
• Acrid Leukorrhea
• Trembling of hands. Hemiplegia
• Ulcers
• Fever: afternoon, low grade, prolonged.

Remedies

1. NIT-AC, ARS
2. PHOS, MERC, SUL
3. Carb-an, Hep, Kali-i, Nat-m
4. Nux-v, Ign, Carc, Sec, Guaj, Colch, Kali-p, Phyt, Pyrog